CRLF2 recombinant protein

Recombinant Mouse CRLF2 Protein

Cat. Num. AAA8248837

• Gene Names: Crlf2; CRLM2; Ly114; Tpte2; Tslpr
• Reactivity: Mouse
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: CRLF2; Recombinant Mouse CRLF2 Protein; CRL2; ILXR; TSLPR; Cytokine receptor-like factor 2; Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor; CRLF2 recombinant protein

• Host: Human cells
• Reactivity: Mouse
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence: AAAVTSRGDV TVVCHDLETV EVTWGSGPDH HSANLSLEFR YGTGALQPCP RYFLSGAGVT SGCILPAARA GLLELALRDG GGAMVFKARQ RASAWLKPRP PWNVTLLWTP DGDVTVSWPA HSYLGLDYEV QHRESNDDED AWQTTSGPCC DLTVGGLDPA RCYDFRVRAS PRAAHYGLEA QPSEWTAVTR LSGAASAASC TASPAPSPAL APPLVDDIEG RMDEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
• Sequence Length: 370

• Applicable Applications for CRLF2 recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for CRLF2 recombinant protein

Recombinant Mouse CRLF2 Protein is produced by our mammalian expression system and the target gene encoding Ala20-Leu233 is expressed with a Fc tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 257900528
• NCBI GeneID: 57914
• NCBI Accession #: NP_001158207.1
• NCBI GenBank Nucleotide #: NM_001164735.1
• UniProt Accession #: Q8CII9; Q9CRJ6; Q9JIE7; Q9JIQ7; Q9JJH8; Q9JMD5
• Molecular Weight: 13,236 Da
• NCBI Official Full Name: cytokine receptor-like factor 2 isoform 1
• NCBI Official Synonym Full Names: cytokine receptor-like factor 2
• NCBI Official Symbol: Crlf2
• NCBI Official Synonym Symbols: CRLM2; Ly114; Tpte2; Tslpr
• NCBI Protein Information: cytokine receptor-like factor 2
• UniProt Protein Name: Cytokine receptor-like factor 2
• Protein Family: Cytokine receptor-like factor
• UniProt Gene Name: Crlf2
• UniProt Synonym Gene Names: Crlm2; Tpte2; Tslpr; CRLM-2; TSLP receptor
• UniProt Entry Name: CRLF2_MOUSE

Uniprot Description

CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: immunoglobulin secretion during immune response; inflammatory response