Corticotropin-releasing factor receptor 1 (Crhr1) Recombinant Protein | Crhr1 recombinant protein
Recombinant Mouse Corticotropin-releasing factor receptor 1 (Crhr1)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Description
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2
Cellular Component: apical part of cell; cell soma; cytosol; dendrite; endosome; integral to membrane; intrinsic to plasma membrane; membrane; multivesicular body; plasma membrane; trans-Golgi network; vesicle
Molecular Function: corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; G-protein alpha-subunit binding; G-protein coupled receptor activity; peptide binding; protein complex binding; signal transducer activity; transmembrane receptor activity
Biological Process: adrenal gland development; adrenocorticotropin hormone secretion; behavioral response to cocaine; behavioral response to ethanol; behavioral response to pain; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; epithelial cell differentiation; fear response; feeding behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); general adaptation syndrome, behavioral process; hormone-mediated signaling; memory; negative regulation of epinephrine secretion; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; positive regulation of mast cell degranulation; regulation of synaptic plasticity; response to electrical stimulus; response to hypoxia; signal transduction; visual learning
Research Articles on Crhr1
Similar Products
Product Notes
The Crhr1 crhr1 (Catalog #AAA7013047) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-415. Full Length of Mature Protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Crhr1 crhr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SLQDQQCESL SLASNVSGLQ CNASVDLIGT CWPRSPAGQL VVRPCPAFFY GVRYNTTNNG YRECLANGSW AARVNYSECQ EILNEEKKSK VHYHIAVIIN YLGHCISLVA LLVAFVLFLR LRSIRCLRNI IHWNLISAFI LRNATWFVVQ LTVSPEVHQS NVAWCRLVTA AYNYFHVTNF FWMFGEGCYL HTAIVLTYST DRLRKWMFVC IGWGVPFPII VAWAIGKLYY DNEKCWFGKR PGVYTDYIYQ GPMILVLLIN FIFLFNIVRI LMTKLRASTT SETIQYRKAV KATLVLLPLL GITYMLFFVN PGEDEVSRVV FIYFNSFLES FQGFFVSVFY CFLNSEVRSA IRKRWRRWQD KHSIRARVAR AMSIPTSPTR VSFHSIKQST AV . It is sometimes possible for the material contained within the vial of "Corticotropin-releasing factor receptor 1 (Crhr1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
