Cellular Repressor Of E1A Stimulated Genes 1 Recombinant Protein | CREG1 recombinant protein

Recombinant Cellular Repressor Of E1A Stimulated Genes 1 (CREG1)

Cat. Num. AAA2033504

• Gene Names: CREG1; CREG
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Cellular Repressor Of E1A Stimulated Genes 1; Recombinant Cellular Repressor Of E1A Stimulated Genes 1 (CREG1); CREG1 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: STIKEV RGWPFADIIS ISDGPPGEGTGEPYMYLSPL QQAVSDLQEN PEATLTMSLA QTVYCRNHGF DPQSPLCVHIMMSGTVTKVN KTEEDYARDS LFVRHPEMKH WPSSHNWFFA KLKISRIWVLDYFGGPKVVT PEEYFNVTLQ
• Sequence Length: 220

• Applicable Applications for CREG1 recombinant protein: SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).
• Predicted Molecular Mass: 20.3kDa
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Endotoxin Level: <1.0EU per 1 ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Fragment: Ser75~Gln220
• Organism Species: Mouse
• Tag: two N-terminal Tags, His-tag and T7-tag
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 14250391
• NCBI GeneID: 8804
• Molecular Weight: 24,075 Da
• NCBI Official Full Name: Cellular repressor of E1A-stimulated genes 1
• NCBI Official Synonym Full Names: cellular repressor of E1A stimulated genes 1
• NCBI Official Symbol: CREG1
• NCBI Official Synonym Symbols: CREG
• NCBI Protein Information: protein CREG1
• UniProt Protein Name: Protein CREG1
• Protein Family: Protein
• UniProt Gene Name: CREG1
• UniProt Synonym Gene Names: CREG
• UniProt Entry Name: CREG1_HUMAN

NCBI Description

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

CREG1: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Belongs to the CREG family.

Protein type: Secreted; Transcription, coactivator/corepressor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: extracellular space; transcription factor complex

Molecular Function: FMN binding; oxidoreductase activity; transcription corepressor activity; transcription factor binding

Biological Process: cell proliferation; multicellular organismal development; regulation of growth; regulation of transcription from RNA polymerase II promoter