Ceruloplasmin (Cp) Recombinant Protein | Cp recombinant protein

Recombinant Mouse Ceruloplasmin (Cp) , partial

• Gene Names: Cp; D3Ertd555e
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ceruloplasmin (Cp); Recombinant Mouse Ceruloplasmin (Cp); partial; Cp recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,061

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Cp recombinant protein

This protein is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.

NCBI and Uniprot Product Information

• NCBI GI #: 442745912
• NCBI GeneID: 12870
• NCBI Accession #: NP_001263177.1
• NCBI GenBank Nucleotide #: NM_001276248.1
• UniProt Accession #: Q61147; Q6P5C8
• Molecular Weight: 121,151 Da
• NCBI Official Full Name: ceruloplasmin isoform c
• NCBI Official Synonym Full Names: ceruloplasmin
• NCBI Official Symbol: Cp
• NCBI Official Synonym Symbols: D3Ertd555e
• NCBI Protein Information: ceruloplasmin
• UniProt Protein Name: Ceruloplasmin
• Protein Family: Ceruloplasmin
• UniProt Gene Name: Cp

NCBI Description

The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Uniprot Description

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense ().