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EZH1 blocking peptide

EZH1 Immunizing Peptide

Gene Names
EZH1; KMT6B
Reactivity
Human, Mouse, Cow
Synonyms
EZH1; EZH1 Immunizing Peptide; enhancer of zeste homolog 1 (Drosophila); KIAA0388; EZH1 blocking peptide
Ordering
For Research Use Only!
Reactivity
Human, Mouse, Cow
Form/Format
100ug of dried peptide
Sequence
EIPNPPTSKCITY
Sequence Length
747
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
68,961 Da
NCBI Official Full Name
histone-lysine N-methyltransferase EZH1 isoform 1
NCBI Official Synonym Full Names
enhancer of zeste 1 polycomb repressive complex 2 subunit
NCBI Official Symbol
EZH1
NCBI Official Synonym Symbols
KMT6B
NCBI Protein Information
histone-lysine N-methyltransferase EZH1
UniProt Protein Name
Histone-lysine N-methyltransferase EZH1
UniProt Gene Name
EZH1
UniProt Synonym Gene Names
KIAA0388
UniProt Entry Name
EZH1_HUMAN

NCBI Description

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]

Uniprot Description

EZH1: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Belongs to the histone-lysine methyltransferase family. EZ subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 17q21.1-q21.3

Cellular Component: ESC/E(Z) complex; nucleoplasm

Molecular Function: chromatin binding; histone-lysine N-methyltransferase activity

Biological Process: anatomical structure morphogenesis; hippocampus development; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

Research Articles on EZH1

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Product Notes

The EZH1 ezh1 (Catalog #AAA426612) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The EZH1 Immunizing Peptide reacts with Human, Mouse, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: EIPNPPTSKC ITY. It is sometimes possible for the material contained within the vial of "EZH1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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