RAP1 / TERF2IP Blocking Peptide | TERF2IP blocking peptide
RAP1 / TERF2IP Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]
Uniprot Description
TERF2IP: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. Ubiquitous. Highly expressed. Belongs to the RAP1 family.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: chromosome, telomeric region; cytoplasm; Mre11 complex; nuclear chromosome; nuclear chromosome, telomeric region; nuclear envelope; nuclear telomere cap complex; nucleoplasm; nucleus
Molecular Function: protein binding; telomeric DNA binding
Biological Process: activation of NF-kappaB transcription factor; negative regulation of DNA recombination at telomere; negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of peptidyl-serine phosphorylation; protection from non-homologous end joining at telomere; regulation of transcription, DNA-dependent; telomere capping; telomere maintenance; telomere maintenance via telomerase; transcription, DNA-dependent
Research Articles on TERF2IP
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Product Notes
The TERF2IP terf2ip (Catalog #AAA427255) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The RAP1 / TERF2IP Immunizing Peptide reacts with Human, Mouse, Rat, Cow, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-GAQNVARR IEFRKK. It is sometimes possible for the material contained within the vial of "RAP1 / TERF2IP, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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