APPL1 blocking peptide
APPL1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
Uniprot Description
APPL: an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage.
Protein type: Nuclear receptor co-regulator; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: cytoplasm; cytosol; early endosome membrane; endosome membrane; nucleus; NuRD complex; vesicle membrane
Molecular Function: identical protein binding; protein binding; protein kinase B binding
Biological Process: cell cycle; cell proliferation; insulin receptor signaling pathway; regulation of glucose import; signal transduction
Disease: Maturity-onset Diabetes Of The Young, Type 14
Research Articles on APPL1
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Product Notes
The APPL1 appl1 (Catalog #AAA426327) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The APPL1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-NRYSRLSK KRENDK. It is sometimes possible for the material contained within the vial of "APPL1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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