GATA3 blocking peptide
GATA3 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Uniprot Description
GATA3: a transcriptional regulator central in Th2 cell differentiation. Inhibits breast cancer growth and pulmonary breast cancer metastasis. Represses INK4C transcription, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland. High GATA3 and low INK4C expression predicts a favorable patient outcome in luminal A type breast tumors. IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human T cells. GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness, and renal dysplasia) syndrome. Two alternatively spliced human isoforms have been described.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: nuclear chromatin; nucleolus; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding; protein binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: anatomical structure formation; anatomical structure morphogenesis; blood coagulation; cell fate commitment; cell fate determination; defense response; ear development; gut development; heart development; kidney development; male gonad development; mesonephros development; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of mammary gland epithelial cell proliferation; negative regulation of transcription, DNA-dependent; norepinephrine biosynthetic process; organ morphogenesis; pharyngeal system development; phosphoinositide 3-kinase cascade; positive regulation of interleukin-4 production; positive regulation of protein kinase B signaling cascade; positive regulation of signal transduction; positive regulation of T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cytokine biosynthetic process; response to estrogen stimulus; response to virus; signal transduction; sympathetic nervous system development; T cell receptor signaling pathway; TOR signaling pathway; transcription from RNA polymerase II promoter; uterus development
Disease: Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Research Articles on GATA3
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Product Notes
The GATA3 gata3 (Catalog #AAA425389) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GATA3 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: EVTADQPRWV SHH-C. It is sometimes possible for the material contained within the vial of "GATA3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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