BCL7A blocking peptide

BCL7A Immunizing Peptide

Cat. Num. AAA426915

• Gene Names: BCL7A; BCL7
• Reactivity: Human, Mouse, Rat, Dog, Cow, Pig
• Synonyms: BCL7A; BCL7A Immunizing Peptide; BCL7; B-cell CLL/lymphoma 7A; B-cell CLL/lymphoma-7; BCL7A blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Cow, Pig
• Form/Format: 100ug of dried peptide
• Sequence: C-MKLEASQQNSEEM
• Sequence Length: 231

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 10337613
• NCBI GeneID: 605
• NCBI Accession #: NP_066273.1; NP_001019979.1
• NCBI GenBank Nucleotide #: NM_020993.4
• Molecular Weight: 25,029 Da
• NCBI Official Full Name: B-cell CLL/lymphoma 7 protein family member A isoform a
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 7A
• NCBI Official Symbol: BCL7A
• NCBI Official Synonym Symbols: BCL7
• NCBI Protein Information: B-cell CLL/lymphoma 7 protein family member A
• UniProt Protein Name: B-cell CLL/lymphoma 7 protein family member A
• Protein Family: B-cell CLL/lymphoma 7 protein family
• UniProt Gene Name: BCL7A
• UniProt Entry Name: BCL7A_HUMAN

NCBI Description

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Bcl-7A: Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. Belongs to the BCL7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 12q24.13

Molecular Function: protein binding

Biological Process: negative regulation of transcription, DNA-dependent