UBR2 blocking peptide

UBR2 Immunizing Peptide

Cat. Num. AAA425808

• Gene Names: UBR2; C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3
• Reactivity: Human, Mouse, Dog, Cow
• Synonyms: UBR2; UBR2 Immunizing Peptide; ubiquitin protein ligase E3 component n-recognin 2; C6orf133; DKFZp686C08114; KIAA0349; MGC71112; RP3-392M17.3; bA49A4.1; dJ242G1.1; dJ392M17.3; OTTHUMP00000016403; OTTHUMP00000016405; OTTHUMP00000039767; OTTHUMP00000039768; ubiquitin ligase E3 alph; UBR2 blocking peptide

• Reactivity: Human, Mouse, Dog, Cow
• Form/Format: 100ug of dried peptide
• Sequence: SCPKSGGDKSRAPT
• Sequence Length: 1755

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 27597061
• NCBI GeneID: 23304
• NCBI Accession #: NP_056070.1
• NCBI GenBank Nucleotide #: NM_015255.2
• Molecular Weight: 200,540 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase UBR2 isoform 1
• NCBI Official Synonym Full Names: ubiquitin protein ligase E3 component n-recognin 2
• NCBI Official Symbol: UBR2
• NCBI Official Synonym Symbols: C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3
• NCBI Protein Information: E3 ubiquitin-protein ligase UBR2
• UniProt Protein Name: E3 ubiquitin-protein ligase UBR2
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: UBR2
• UniProt Synonym Gene Names: C6orf133; KIAA0349
• UniProt Entry Name: UBR2_HUMAN

NCBI Description

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Description

UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: chromatin; cytoplasm; cytosol; nucleoplasm; plasma membrane; ubiquitin ligase complex

Molecular Function: ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: chromatin silencing; histone H2A ubiquitination; male meiosis I; negative regulation of TOR signaling pathway; protein polyubiquitination; spermatogenesis