Specific Activity
(Binding of Anti-2019-nCoV N-Protein Antibody ( MBS515752 ) to immobilized 2019-nCoV Nucleocapsid (N) Protein (MBS515760) determined by ELISA using Goat anti-human Fc-HRP.)
COVID 19 Nucleocapsid (NP) Coronavirus Recombinant Protein | COVID-19 recombinant protein
2019-nCoV Nucleocapsid (N) Protein
Synonyms
COVID 19 Nucleocapsid (NP) Coronavirus; 2019-nCoV Nucleocapsid (N) Protein; 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Nucleocapsid; Nucleoprotein (NP); COVID-19 recombinant protein
Host
E Coli
Form/Format
10mM PBS, pH8.0, 50mM NaCl, 0.05% Na3N
Species
SARS-CoV-2
Tag
HIS
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity
(Binding of Anti-2019-nCoV N-Protein Antibody ( MBS515752 ) to immobilized 2019-nCoV Nucleocapsid (N) Protein (MBS515760) determined by ELISA using Goat anti-human Fc-HRP.)
Specific Activity
(Binding of Anti-2019-nCoV N-Protein Antibody ( MBS515752 ) to immobilized 2019-nCoV Nucleocapsid (N) Protein (MBS515760) determined by ELISA using Goat anti-human Fc-HRP.)
Purity Data
(The purity was determined to be >90% by densitometry. Approx. MW 52kDa)
Purity Data
(The purity was determined to be >90% by densitometry. Approx. MW 52kDa)
Related Product Information for COVID-19 recombinant protein
Recombinant full-length 2019-nCoV Nucleocapsid (N) Protein was expressed in E Coli cells with a C-terminal His tag.
Overview: CoV N-protein is an RNA-binding protein primarily involved in binding to the viral RNA genome during packaging of viral RNA into a helical ribonucleoproteins or nucelocapsid structure (1). In addition, N-protein regulates viral RNA synthesis during replication/transcription and modulates host-pathogen interactions, such as such as actin reorganization, host cell cycle progression, and apoptosis (2). N-protein is abundantly expressed during infection and antibodies against N-protein have been detected in confirmed cases of Covid-19. Therefore, N-protein is a potent antigen that provides basis for future vaccine and test kit development (3).
Overview: CoV N-protein is an RNA-binding protein primarily involved in binding to the viral RNA genome during packaging of viral RNA into a helical ribonucleoproteins or nucelocapsid structure (1). In addition, N-protein regulates viral RNA synthesis during replication/transcription and modulates host-pathogen interactions, such as such as actin reorganization, host cell cycle progression, and apoptosis (2). N-protein is abundantly expressed during infection and antibodies against N-protein have been detected in confirmed cases of Covid-19. Therefore, N-protein is a potent antigen that provides basis for future vaccine and test kit development (3).
Product Categories/Family for COVID-19 recombinant protein
References
1. McBride R, et al: The Corona virus nucleocapsid is a multifunctional protein. Viruses. 2014, 6:2991-3018.
2. Surjit M, et al: The nucleocapsid protein of severe acute respiratory syndrome-Corona virus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem. 2006, 281:10669-10681
3. Zeng W, et al: Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 2020, 527(3):618?623.
2. Surjit M, et al: The nucleocapsid protein of severe acute respiratory syndrome-Corona virus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem. 2006, 281:10669-10681
3. Zeng W, et al: Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 2020, 527(3):618?623.
NCBI and Uniprot Product Information
Molecular Weight
52kDa
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Product Notes
The COVID-19 (Catalog #AAA515760) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "COVID 19 Nucleocapsid (NP) Coronavirus, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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