Typical Testing Data/Standard Curve (for reference only)
Human COVID 19 ACE2 Binding Inhibitor Coronavirus Assay Kit | COVID-19 assay kit
SARS-CoV-2 S1 Protein-ACE2 Binding Inhibitor Screening Kit
Reactivity
Human
Synonyms
COVID 19 ACE2 Binding Inhibitor Coronavirus; SARS-CoV-2 S1 Protein-ACE2 Binding Inhibitor Screening Kit; 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; ACE2 Binding Inhibitor; COVID-19 assay kit
Reactivity
Human
Preparation and Storage
Store at -20 degree C
Shipping: Gel Pack
Shelf Life: Est.~12 months
Shipping: Gel Pack
Shelf Life: Est.~12 months
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for COVID-19 assay kit
Background/Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), also known as the 2019 Novel Coronavirus (2019-nCoV) or human coronavirus 2019 (HCoV-19 or hCoV-19), is the cause of the Coronavirus Disease 2019 (COVID-19) pandemic. It is a RNA virus that causes severe respiratory diseases in humans. SARS-CoV-2 coronavirus contains four main structural proteins namely Spike (S), Membrane (M), Envelope (E), and Nucleocapsid (N) protein. Spike protein is located on the outer envelope of the virion and mediates the viral entry and thus, plays an important role in inducing neutralizing antibodies and protective immunity. S protein consists of S1 and S2 subunits. The S1 subunit contains a receptor-binding domain that can specifically bind to the host-receptor namely Angiotensin Converting Enzyme 2 (ACE2), which facilitates the entry of the virus into the target cells including respiratory or intestinal epithelial cells, endothelial cells, alveolar monocytes or macrophages. The receptor recognition step is an important determinant of the viral infectivity, pathogenesis & host range. Therefore, an intervention strategy that targets S1 protein and ACE2 interaction presents an important target for vaccination or antiviral strategies that includes small molecules and therapeutic antibodies. The SARS-CoV-2 S1 Protein-ACE2 Binding Inhibitor Screening Kit can be used to screen for potential inhibitors of S1 protein binding to human ACE2. In this assay, the binding of S1 protein to biotinylated human ACE2 is detected using Streptavidin-HRP. Subsequently, a TMB substrate is added to visualize the HRP enzymatic reaction thereby generating a blue colored product that changes to yellow once the stop solution is added. The density of the yellow color is proportional to the binding of S1 protein to Human ACE2. However, in the presence of potent inhibitor(s), the binding of S1 protein to Human ACE2 is suppressed thereby preventing the color generation. The assay kit is adapted to a 96-well format and provides a reliable test for high throughput screening of potential inhibitors of S1 protein binding to Human ACE2.
Product Categories/Family for COVID-19 assay kit
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Product Notes
The Human COVID-19 (Catalog #AAA8400632) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8400632 Assay Kit recognizes Human COVID-19. It is sometimes possible for the material contained within the vial of "COVID 19 ACE2 Binding Inhibitor Coronavirus, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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