Kinesin-like protein costa (cos) Recombinant Protein | cos recombinant protein

Recombinant Drosophila melanogaster Kinesin-like protein costa (cos), partial

• Gene Names: cos; CG1708; Cos; cos-2; Cos-2; cos2; Cos2; COS2; Cos[2]; COS[2]; DmCos2; DmelCG1708; KIF26A/B; Kif7; l(2)161/28; l(2)cos[[2]]; l(2)k16101; l(2)k16128
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Kinesin-like protein costa (cos); Recombinant Drosophila melanogaster Kinesin-like protein costa (cos); partial; cos recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1201

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 442622695
• NCBI GeneID: 35653
• NCBI Accession #: NP_001260765.1
• NCBI GenBank Nucleotide #: NM_001273836.1
• UniProt Accession #: O16844; Q6AWI9; Q8IH04; A1Z6X4; B5RIP3
• Molecular Weight: 133,148 Da
• NCBI Official Full Name: costa, isoform B
• NCBI Official Synonym Full Names: costa
• NCBI Official Symbol: cos
• NCBI Official Synonym Symbols: CG1708; Cos; cos-2; Cos-2; cos2; Cos2; COS2; Cos[2]; COS[2]; DmCos2; DmelCG1708; KIF26A/B; Kif7; l(2)161/28; l(2)cos[[2]]; l(2)k16101; l(2)k16128
• NCBI Protein Information: CG1708 gene product from transcript CG1708-RA
• UniProt Protein Name: Kinesin-like protein costa
• Protein Family: Kinesin-like protein
• UniProt Gene Name: cos
• UniProt Synonym Gene Names: cos2; costal-2

Uniprot Description

Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. Negatively regulates hh-signaling pathways during various processes, including photoreceptor differentiation (PubMed:25639794, PubMed:27195754). May negatively regulate a hh-signaling pathway which functions in the intestinal immune response to bacterial uracil by activating the Duox-dependent production of reactive oxygen species (ROS) (PubMed:25639794).