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Coronin-6/CORO6 Recombinant Protein | CORO6 recombinant protein
Recombinant Human Coronin-6/CORO6 Protein (His Tag)
Purity
> 95 % as determined by reducing SDS-PAGE.
Synonyms
Coronin-6/CORO6; Recombinant Human Coronin-6/CORO6 Protein (His Tag); Coronin-6; Clipin-E; CORO6; CORO6 recombinant protein
Host
E.coli
Purity/Purification
> 95 % as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 1mM DTT,pH 7.4
Concentration
0.67mg/mL (varies by lot)
Sequence Positions
Met 1-Asp237
Species
Human
Tag
N-6His
Endotoxin
< 1.0 EU per ug as determined by the LAL method.
Preparation and Storage
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Western Blot (WB)
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Related Product Information for CORO6 recombinant protein
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is prominently expressed in adult muscle and enriched at the NMJ. Studies with cultured myotubes reveal that Coronin 6 regulates both agrin- and laminin-induced AChR clustering and is important for anchoring AChRs onto the actin cytoskeleton. Also, both the C-terminal region and a conserved Arg29 residue at the N terminus of Coronin 6 are essential for its actin-binding activity and stabilization of AChR–cytoskeleton linkage. Importantly, in vivo knockdown of Coronin 6 in mouse skeletal muscle fibers leads to destabilization of AChR clusters, which demonstrates that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the NMJs through modulating the receptor-anchored actin cytoskeleton. The human Coronin 6 has five isoforms produced by alternative splicing, and tissue specific expression of these isoforms are unclear.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
coronin-6 isoform 1
NCBI Official Synonym Full Names
coronin 6
NCBI Official Symbol
CORO6
NCBI Protein Information
coronin-6
UniProt Protein Name
Coronin-6
Protein Family
UniProt Gene Name
CORO6
UniProt Synonym Gene Names
Clipin-E
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Product Notes
The CORO6 coro6 (Catalog #AAA2552530) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met 1-Asp237. It is sometimes possible for the material contained within the vial of "Coronin-6/CORO6, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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