Coatomer subunit beta (Copb1) Recombinant Protein | Copb1 recombinant protein

Recombinant Rat Coatomer subunit beta (Copb1) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Coatomer subunit beta (Copb1); Recombinant Rat Coatomer subunit beta (Copb1); partial; Copb1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 953

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Copb1 recombinant protein

This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 18158449
• NCBI GeneID: 114023
• NCBI Accession #: NP_542959.1
• NCBI GenBank Nucleotide #: NM_080781.2
• UniProt Accession #: P23514
• Molecular Weight: 107,011 Da
• NCBI Official Full Name: coatomer subunit beta
• NCBI Official Synonym Full Names: coatomer protein complex, subunit beta 1
• NCBI Official Symbol: Copb1
• NCBI Protein Information: coatomer subunit beta
• UniProt Protein Name: Coatomer subunit beta
• UniProt Gene Name: Copb1
• UniProt Synonym Gene Names: Copb; Beta-COP

NCBI Description

transmembrane protein associated with the Golgi; may be a component of non-clathrin coated vesicles and cisternae of the Golgi complex [RGD, Feb 2006]

Uniprot Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins in the axonal compartment of dorsal root ganglion (DRG) cells. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.