Competence pheromone (comX) Recombinant Protein | comX recombinant protein
Recombinant Bacillus subtilis Competence pheromone (comX)
NCBI and Uniprot Product Information
Uniprot Description
Function: Part of a major quorum-sensing system that regulates the development of genetic competence. Acts through the activation of the two-component regulatory system ComP/ComA composed of a sensor histidine kinase, ComP, and a response regulator, ComA, that regulates directly the transcription of over 20 genes. Transport through the membrane may involve Spo0K. Under certain conditions plays a role in sporulation. Ref.7
Subcellular location: Secreted.
Post-translational modification: Trp-53 is modified by isoprenylation, probably by farnesylation, which is essential for activity. The type of isoprenyl derivative differs among the different pherotypes and depends on ComX primary sequence. ComQ is required for the production of ComX and may be responsible alone for its complete maturation.
Miscellaneous: The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus. In ComX, the sole conserved residue is the modified tryptophan essential for the activity.
Research Articles on comX
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Product Notes
The comX comx (Catalog #AAA1022914) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 46-55aa; Full Length of Mature Protein. The amino acid sequence is listed below: ADPITRQWGD. It is sometimes possible for the material contained within the vial of "Competence pheromone (comX), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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