Collagen Type IV Alpha 3 Recombinant Protein | COL4A3BP recombinant protein

Recombinant Human Collagen Type IV Alpha 3 Binding Protein

Cat. Num. AAA143961

• Gene Names: COL4A3BP; CERT; GPBP; CERTL; STARD11
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Collagen Type IV Alpha 3; Recombinant Human Collagen Type IV Alpha 3 Binding Protein; COL4A3BP Human; Collagen Type IV Alpha 3 Binding Protein Human Recombinant; COL4A3BP; FLJ20597; Collagen type IV alpha-3-binding protein; GPBP; STARD11; CERT; HCERT; CERTL; Ceramide Transfer Protein; Goodpasture antigen-binding protein; StAR-related lipid transfer protein 11; START domain-containing protein 11; COL4A3BP recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: COL4A3BP Human solution containing 20mM Tris HCL pH-8, 0.1M NaCl, & 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWAGSMLH WPTSLPSGDA FSSVGTHRFV QKVEEMVQNH MTYSLQDVGG DANWQLVVEE GEMKVYRREV EENGIVLDPL KATHAVKGVT GHEVCNYFWN VDVRNDWETT IENFHVVETL ADNAIIIYQT HKRVWPASQR DVLYLSVIRK IPALTENDPE TWIVCNFSVD HDSAPLNNRC VRAKINVAMI CQTLVSPPEG NQEISRDNIL CKITYVANVN PGGWAPASVL RAVAKREYPK FLKRFTSYVQ EKTAGKPILF
• Sequence Length: 752

• Preparation and Storage: COL4A3BP Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Related Product Information for COL4A3BP recombinant protein

Description: COL4A3BP Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 290 amino acids (347-598 a.a.) and having a molecular mass of 33.1 kDa. The COL4A3BP is fused to 38 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: COL4A3BP is a kinase that particularly phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, recognized as the Goodpasture antigen that is the outcome of an autoimmune reaction directed at COL4A3BP. One isoform of COL4A3BP participates in ceramide intracellular transport.

Product Categories/Family for COL4A3BP recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Collagen

NCBI and Uniprot Product Information

• NCBI GI #: 194294543
• NCBI GeneID: 10087
• NCBI Accession #: NP_001123577.1
• NCBI GenBank Nucleotide #: NM_001130105.1
• UniProt Accession #: Q9Y5P4; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; A8K7S2; B3KUB7
• Molecular Weight: 83,708 Da
• NCBI Official Full Name: collagen type IV alpha-3-binding protein isoform 3
• NCBI Official Synonym Full Names: collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
• NCBI Official Symbol: COL4A3BP
• NCBI Official Synonym Symbols: CERT; GPBP; CERTL; STARD11
• NCBI Protein Information: collagen type IV alpha-3-binding protein; StAR-related lipid transfer (START) domain containing 11; ceramide transfer protein; ceramide transporter; hCERT; lipid-transfer protein CERTL
• UniProt Protein Name: Collagen type IV alpha-3-binding protein
• Protein Family: Collagen type IV alpha-3-binding protein
• UniProt Gene Name: COL4A3BP
• UniProt Synonym Gene Names: CERT; STARD11; hCERT; GPBP; StARD11
• UniProt Entry Name: C43BP_HUMAN

NCBI Description

This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

COL4A3BP: a protein with a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. Implicated in human autoimmune diseases via its association with the Goodpasture antigen. Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. GPBP has been reported to have Ser/Thr protein kinase activity towards the Goodpasture (GP) antigen, but lacks a conventional serine/threonine kinase domain. Two human isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.9; Protein kinase, atypical; Lipid-binding; ATYPICAL group; COL4A3BP family

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; cytosol

Molecular Function: protein binding; protein kinase activity

Biological Process: endoplasmic reticulum organization and biogenesis; heart morphogenesis; sphingolipid metabolic process; sphingolipid biosynthetic process; in utero embryonic development; cell morphogenesis; lipid homeostasis; signal transduction; protein amino acid phosphorylation; cell proliferation; muscle contraction; immune response; ceramide metabolic process

Disease: Mental Retardation, Autosomal Dominant 34