CASPR2 Recombinant Protein | CNTNAP2 recombinant protein

CASPR2 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122890

• Gene Names: Cntnap2; Caspr2; mKIAA0868; 5430425M22Rik
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CASPR2; CASPR2 Protein; Mouse; Recombinant (His Tag); Mouse CNTNAP2/CASPR2 Protein (His Tag); 5430425M22Rik Protein; Caspr2 Protein; mKIAA0868 Protein; contactin associated protein-like 2; CNTNAP2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ser1262

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Ala 28
• Tag: C-His
• Protein Construction: A DNA sequence encoding the extracellular domain of mouse CASPR2 (NP_001004357.2)(Met 1-Ser 1262) was expressed, with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CNTNAP2 recombinant protein

Background: CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction.

References

Poot M, et al. (2010) Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder. Neurogenetics. 11(1): 81-9.Friedman JI, et al. (2008) CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Mol Psychiatry. 13(3): 261-6.Verkerk AJ, et al. (2003) CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics. 82(1): 1-9.

NCBI and Uniprot Product Information

• NCBI GI #: 165377150
• NCBI GeneID: 66797
• NCBI Accession #: NP_001004357.2
• NCBI GenBank Nucleotide #: NM_001004357.2
• UniProt Accession #: Q9CPW0; Q6P2K4; Q6ZQ31
• Molecular Weight: 148,197 Da
• NCBI Official Full Name: contactin-associated protein-like 2 isoform a
• NCBI Official Synonym Full Names: contactin associated protein-like 2
• NCBI Official Symbol: Cntnap2
• NCBI Official Synonym Symbols: Caspr2; mKIAA0868; 5430425M22Rik
• NCBI Protein Information: contactin-associated protein-like 2; cell recognition molecule Caspr2
• UniProt Protein Name: Contactin-associated protein-like 2
• Protein Family: Contactin-associated protein
• UniProt Gene Name: Cntnap2
• UniProt Synonym Gene Names: Kiaa0868
• UniProt Entry Name: CNTP2_MOUSE