Calcium/calmodulin-dependent protein kinase type 1 (cmk-1) Recombinant Protein | cmk-1 recombinant protein

Recombinant Caenorhabditis elegans Calcium/calmodulin-dependent protein kinase type 1 (cmk-1)

Cat. Num. AAA1442968

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Calcium/calmodulin-dependent protein kinase type 1 (cmk-1); Recombinant Caenorhabditis elegans Calcium/calmodulin-dependent protein kinase type 1 (cmk-1); cmk-1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-348, Full length
• Sequence: MPLFKRRDGSGPAPNATIREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVLEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSKTEDSGVMATACGTPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWISGNTAYTHDIHGTVAVHLKKSLAKRNWKKAYNAAAAIRQLQMLRLSSNSNRLQKQASQQQPEPPTPAFHA
• Sequence Length: 348

• Species: Caenorhabditis elegans
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 17539480
• NCBI GeneID: 176989
• NCBI Accession #: NP_500139.1
• NCBI GenBank Nucleotide #: NM_067738.6
• UniProt Accession #: Q9TXJ0; Q6V5R5; Q9UAH6
• Molecular Weight: 39,124 Da
• NCBI Official Full Name: Calcium/calmodulin-dependent protein kinase type 1
• NCBI Official Symbol: cmk-1
• NCBI Protein Information: Calcium/calmodulin-dependent protein kinase type 1
• UniProt Protein Name: Calcium/calmodulin-dependent protein kinase type 1
• Protein Family: Calcium/calmodulin-dependent protein kinase
• UniProt Gene Name: cmk-1
• UniProt Synonym Gene Names: CaM-KI

Uniprot Description

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation (PubMed:10428833, PubMed:12231504, PubMed:26725111). Transcriptional activation occurs at least in part through phosphorylation of crh-1 (PubMed:10428833, PubMed:12231504). Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons (PubMed:10428833, PubMed:14711416, PubMed:25467978). Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature (PubMed:25467978). Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious heat and controls neuropeptide release from FLP neurons in response to temperature elevations (PubMed:25467982). Regulates the dauer decision, the decision of the larvae to enter into the alternative stress-resistant and long-lived dauer developmental stage, based on the feeding state, primarily in the AWC sensory neurons. Acts non cell-autonomously in the AWC neurons to regulate expression of the daf-28 insulin-like peptide and cell-autonomously in the ASI sensory neurons to regulate expression of the growth promoting daf-7 in a food-regulated manner (PubMed:26335407). Plays a role in memory-based thermal response of an individual AFD neuron cell (PubMed:26725111). Involved in chemotaxis response in AWC neurons to attractant 2-heptanone, a volatile organic compound emitted by the nematode pathogenic bacterium B.nematocida B16 (PubMed:27660389). Represses transcription of glutamate receptor glr-1 in the nucleus basally and in response to change in synaptic activity (PubMed:27462879).