CLEC16A Blocking Peptide | CLEC16A (HGNC:29013) blocking peptide

CLEC16A Blocking Peptide (C-term)

• Gene Names: CLEC16A; Gop-1; KIAA0350
• Synonyms: CLEC16A; CLEC16A Blocking Peptide (C-term); Protein CLEC16A; C-type lectin domain family 16 member A; CLEC16A (HGNC:29013) blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 773-785 of HUMAN CLEC16A (HGNC:29013)
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1053

• Cellular Location: Endosome membrane; Peripheral membrane protein Lysosome membrane; Peripheral membrane protein. Note: Associates with the endolysosome membrane
• Tissue Location: Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CLEC16A (HGNC:29013) blocking peptide

Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.

NCBI and Uniprot Product Information

• NCBI GI #: 125950459
• NCBI GeneID: 23274
• UniProt Accession #: Q2KHT3; O15058; Q6ZTB2
• Molecular Weight: 14,283 Da
• NCBI Official Full Name: Protein CLEC16A
• NCBI Official Synonym Full Names: C-type lectin domain family 16 member A
• NCBI Official Symbol: CLEC16A
• NCBI Official Synonym Symbols: Gop-1; KIAA0350
• NCBI Protein Information: protein CLEC16A
• UniProt Protein Name: Protein CLEC16A
• UniProt Gene Name: CLEC16A
• UniProt Entry Name: CL16A_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

CLEC16A: Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes KIAA0350. Three common non-coding variants of KIAA0350 in strong linkage disequilibrium reach genome-wide significance for association with the disease (PubMed:17632545). Belongs to the CLEC16A/gop-1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 16p13.13