CLC recombinant protein

Recombinant Human CLC protein

Cat. Num. AAA1561512

• Gene Names: CLC; GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CLC; Recombinant Human CLC protein; Galectin-10; Gal-10; Charcot-Leyden crystal protein; Eosinophil lysophospholipase; Lysolecithin acylhydrolase; CLC recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human CLC (Ser2-Arg142) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for CLC recombinant protein

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

Product Categories/Family for CLC recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 20357559
• NCBI GeneID: 1178
• NCBI Accession #: NP_001819.2
• NCBI GenBank Nucleotide #: NM_001828.5
• UniProt Accession #: Q05315; Q0VDE3; C5HZ13; C5HZ14
• Molecular Weight: 16,453 Da
• NCBI Official Full Name: galectin-10
• NCBI Official Synonym Full Names: Charcot-Leyden crystal galectin
• NCBI Official Symbol: CLC
• NCBI Official Synonym Symbols: GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
• NCBI Protein Information: galectin-10; Charcot-Leyden crystal protein; eosinophil lysophospholipase; galectin 10; lectin, galactoside-binding, soluble, 10; lysolecithin acylhydrolase
• UniProt Protein Name: Galectin-10
• Protein Family: Clathrin
• UniProt Gene Name: CLC
• UniProt Synonym Gene Names: LGALS10; LGALS10A; Gal-10; CLC
• UniProt Entry Name: LEG10_HUMAN

NCBI Description

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

Uniprot Description

CLC: May have both lysophospholipase and carbohydrate-binding activities.

Protein type: Phospholipase; EC 3.1.1.5

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytosol

Molecular Function: protein binding; carbohydrate binding; lysophospholipase activity

Biological Process: regulation of activated T cell proliferation; regulation of T cell cytokine production; multicellular organismal development; regulation of T cell anergy