Acetylcholine receptor subunit epsilon (CHRNE) Recombinant Protein | CHRNE recombinant protein

Recombinant Human Acetylcholine receptor subunit epsilon (CHRNE), partial

• Gene Names: CHRNE; ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Acetylcholine receptor subunit epsilon (CHRNE); Recombinant Human Acetylcholine receptor subunit epsilon (CHRNE); partial; CHRNE recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 493

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 4557463
• NCBI GeneID: 1145
• NCBI Accession #: NP_000071.1
• NCBI GenBank Nucleotide #: NM_000080.3
• UniProt Accession #: Q04844; D3DTK6
• Molecular Weight: 54,697 Da
• NCBI Official Full Name: acetylcholine receptor subunit epsilon
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic epsilon subunit
• NCBI Official Symbol: CHRNE
• NCBI Official Synonym Symbols: ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS
• NCBI Protein Information: acetylcholine receptor subunit epsilon
• UniProt Protein Name: Acetylcholine receptor subunit epsilon
• Protein Family: Acetylcholine receptor
• UniProt Gene Name: CHRNE
• UniProt Synonym Gene Names: ACHRE

NCBI Description

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]

Uniprot Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.