Fish M2-Cholinergic Receptor Antibodies ELISA Kit | CHRM2 elisa kit

Fish M2-Cholinergic Receptor Antibodies ELISA Kit

• Gene Names: Chrm2; Acm2
• Reactivity: Fish
• Synonyms: M2-Cholinergic Receptor Antibodies; Fish M2-Cholinergic Receptor Antibodies ELISA Kit; CHRM2 elisa kit

• Reactivity: Fish
• Sequence Length: 466

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13591922
• NCBI GeneID: 81645
• NCBI Accession #: NP_112278.1
• NCBI GenBank Nucleotide #: NM_031016.1
• UniProt Accession #: P10980; Q9Z2Z1
• Molecular Weight: 51,539 Da
• NCBI Official Full Name: muscarinic acetylcholine receptor M2
• NCBI Official Synonym Full Names: cholinergic receptor, muscarinic 2
• NCBI Official Symbol: Chrm2
• NCBI Official Synonym Symbols: Acm2
• NCBI Protein Information: muscarinic acetylcholine receptor M2; 7TM receptor; muscarinic receptor m2; M2 muscarinic acetylcholine receptor; cholinergic receptor, muscarinic 2, cardiac
• UniProt Protein Name: Muscarinic acetylcholine receptor M2
• Protein Family: Muscarinic acetylcholine receptor
• UniProt Gene Name: Chrm2
• UniProt Synonym Gene Names: Chrm-2
• UniProt Entry Name: ACM2_RAT

NCBI Description

may inhibit cholinergic-mediated bronchoconstriction; may regulate bladder contraction [RGD, Feb 2006]

Uniprot Description

mAChR M2: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD). MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Cellular Component: asymmetric synapse; postsynaptic membrane; cell soma; membrane; integral to plasma membrane; dendrite; plasma membrane; nerve terminal; cell junction

Molecular Function: drug binding; G-protein coupled acetylcholine receptor activity

Biological Process: regulation of smooth muscle contraction; synaptic transmission; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); acetylcholine receptor signaling, muscarinic pathway; response to virus; regulation of heart contraction