IL-4 receptor alpha Active Protein | IL-4 active protein
Human IL-4 receptor alpha (CD124), soluble
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Uniprot Description
IL4R: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: interleukin-4 receptor activity; protein binding; receptor signaling protein activity
Biological Process: immune response; signal transduction
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Ige Responsiveness, Atopic
Research Articles on IL-4
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Product Notes
The IL-4 il4r (Catalog #AAA692482) is an Active Protein produced from CHO cells and is intended for research purposes only. The product is available for immediate purchase. The Human IL-4 receptor alpha (CD124), soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLS EAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG S FKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYA VNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WA QCYNTTWS EWSPSTKWHN SYREPFEQH. It is sometimes possible for the material contained within the vial of "IL-4 receptor alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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