ANGPTL3 Active Protein | ANGPTL-3 active protein

Human ANGPTL3

Cat. Num. AAA695890

• Gene Names: ANGPTL3; ANL3; ANG-5; FHBL2; ANGPT5
• Purity: > 98% as determined by SDS-PAGE Analyses.
• Synonyms: ANGPTL3; Human ANGPTL3; Recombinant Human ANGPTL-3; ANGPTL-3 active protein

• Host: CHO cells
• Purity/Purification: > 98% as determined by SDS-PAGE Analyses.
• Form/Format: Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Sodium Phosphate, pH 7.5
• Sequence: SRIDQDNSS FDSLSPEPK SRFAMLDDV KILANGLLQ LGHGLKDFV HKTKGQIND IFQKLNIFD QSFYDLSLQ TSEIKEEEK ELRRTTYKL QVKNEEVKN MSLELNSKL ESLLEEKIL LQQKVKYLE EQLTNLIQN QPETPEHPE VTSLKTFVE KQDNSIKDL LQTVEDQYK QLNQQHSQI KEIENQLRR TSIQEPTEI SLSSKPRAP RTTPFLQLN EIRNVKHDG IPAECTTIY NRGEHTSGM YAIRPSNSQ VFHVYCDVI SGSPWTLIQ HRIDGSQNF NETWENYKY GFGRLDGEF WLGLEKIYS IVKQSNYVL RIELEDWKD NKHYIEYSF YLGNHETNY TLHLVAITG NVPNAIPEN KDLVFSTWD HKAKGHFNC PEGYSGGWW WHDECGENN LNGKYNKPR AKSKPERRR GLSWKSQNG RLYSIKSTK MLIHPTDSE SFEHHHHHH HH

• Biological Activity: Measured by its binding ability to recombinant alpha vbeta3 integrin in a functional ELISA.
• Authenticity: Verified by N-terminal and Mass Spectometry analyses (when applicable).
• Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (<1EU/ug).
• Protein Content: Verified by UV Spectroscopy and/or SDS-PAGE gel.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitutein water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
• Preparation and Storage: At -20°C

Testing Data

Product Categories/Family for ANGPTL-3 active protein

Angiogenesis; Metabolic Regulation and Diabetes

NCBI and Uniprot Product Information

• NCBI GI #: 25008126
• NCBI GeneID: 27329
• UniProt Accession #: Q9Y5C1; A0JLS0; B1ALJ0; B2RCW1
• NCBI Official Full Name: Angiopoietin-related protein 3
• NCBI Official Synonym Full Names: angiopoietin-like 3
• NCBI Official Symbol: ANGPTL3
• NCBI Official Synonym Symbols: ANL3; ANG-5; FHBL2; ANGPT5
• NCBI Protein Information: angiopoietin-related protein 3; angiopoietin 5
• UniProt Protein Name: Angiopoietin-related protein 3
• UniProt Gene Name: ANGPTL3
• UniProt Synonym Gene Names: ANGPT5; ANG-5
• UniProt Entry Name: ANGL3_HUMAN

NCBI Description

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]

Uniprot Description

ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide; Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: extracellular space; cell surface

Molecular Function: integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity

Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; phospholipid catabolic process; glycerol metabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; signal transduction; fatty acid metabolic process; positive regulation of angiogenesis; sequestering of lipid; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis

Disease: Hypobetalipoproteinemia, Familial, 2