alpha Actinin Native Protein | ACTN3 native protein

alpha Actinin protein

Cat. Num. AAA536612

• Applications: User optimized
• Purity: > 95% pure
• Synonyms: alpha Actinin; alpha Actinin protein; alpha Actinin 1 protein; ACTN1 protein; FLJ40884 protein; ACTN3 native protein

• Host: Chicken
• Purity/Purification: > 95% pure
• Form/Format: Supplied in lyophilized form with 10 mM Tris/HCl buffer pH 8.0, 0.2mM CaCl2, 0.2 mM ATP, 1 mM DTT, 0.5% (w/v) SDS
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 901

• Applicable Applications for ACTN3 native protein: User optimized
• Source Note: Chicken gizzard
• Protein Type: Native
• Biological Significance: Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
• Preparation and Storage: Store at 2-8 degree C in lyophilized form. Following reconstitution aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for ACTN3 native protein

Purified native Chicken alpha Actinin protein

Product Categories/Family for ACTN3 native protein

Cell Biology; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 178058
• NCBI GeneID: 89
• UniProt Accession #: Q08043; Q4KKV2; A6NP77
• Molecular Weight: 95 kDa
• NCBI Official Full Name: alpha-actinin
• NCBI Official Synonym Full Names: actinin, alpha 3 (gene/pseudogene)
• NCBI Official Symbol: ACTN3
• NCBI Protein Information: alpha-actinin-3
• UniProt Protein Name: Alpha-actinin-3
• Protein Family: Alpha-actinin
• UniProt Gene Name: ACTN3
• UniProt Entry Name: ACTN3_HUMAN

NCBI Description

This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014]

Uniprot Description

ACTN3: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: focal adhesion; actin filament; pseudopodium; cytosol

Molecular Function: integrin binding; protein binding; protein homodimerization activity; structural constituent of muscle; calcium ion binding; actin binding

Biological Process: focal adhesion formation; regulation of apoptosis; muscle filament sliding