Chicken Antithrombin III (ATIII) ELISA Kit | ATIII elisa kit

Chicken Antithrombin III (ATIII) ELISA Kit

Cat. Num. AAA264843

• Gene Names: SERPINC1; AT3; AT3D; ATIII; THPH7
• Reactivity: Chicken
• Synonyms: Antithrombin III (ATIII); Chicken Antithrombin III (ATIII) ELISA Kit; ATIII elisa kit

• Reactivity: Chicken
• Sequence Length: 464

• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 4502261
• NCBI GeneID: 462
• NCBI Accession #: NP_000479.1
• NCBI GenBank Nucleotide #: NM_000488.3
• Molecular Weight: 52,602 Da
• NCBI Official Full Name: antithrombin-III
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade C (antithrombin), member 1
• NCBI Official Symbol: SERPINC1
• NCBI Official Synonym Symbols: AT3; AT3D; ATIII; THPH7
• NCBI Protein Information: antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
• UniProt Protein Name: Antithrombin-III
• UniProt Gene Name: SERPINC1
• UniProt Synonym Gene Names: AT3; PRO0309; ATIII
• UniProt Entry Name: ANT3_HUMAN

NCBI Description

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Uniprot Description

SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding

Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient

Disease: Antithrombin Iii Deficiency