Human Chitinase 3-Like 1 ELISA Kit | CHI3L1 elisa kit

Chitinase 3-Like 1 (Human) OmniKine ELISA Kit

Cat. Num. AAA9502035

• Gene Names: CHI3L1; GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39
• Reactivity: Human
• Synonyms: Chitinase 3-Like 1; Chitinase 3-Like 1 (Human) OmniKine ELISA Kit; Chitinase-3-like protein 1; 39 kDa synovial protein; Cartilage glycoprotein 39; YKL-40; CHI3L1 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human Chitinase 3-Like 1 ELISA is capable of recognizing both recombinant and naturally produced Human Chitinase 3-Like 1 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross-reactivity or interference.; Human: CHI3L2, Chitotriosidas; Murine: CHI3L1
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 383

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 32-2000 pg/ml
• Sensitivity: 32-2000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human Chitinase 3-Like 1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Chitinase 3-Like 1 proteins within the range of 32-2000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 144226251
• NCBI GeneID: 1116
• NCBI Accession #: NP_001267.2
• NCBI GenBank Nucleotide #: NM_001276.2
• UniProt Accession #: P36222; P30923; Q8IVA4; Q96HI7; B2R7B0
• Molecular Weight: 42,625 Da
• NCBI Official Full Name: chitinase-3-like protein 1
• NCBI Official Synonym Full Names: chitinase 3 like 1
• NCBI Official Symbol: CHI3L1
• NCBI Official Synonym Symbols: GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39
• NCBI Protein Information: chitinase-3-like protein 1
• UniProt Protein Name: Chitinase-3-like protein 1
• Protein Family: Chitinase-3-like protein
• UniProt Gene Name: CHI3L1
• UniProt Synonym Gene Names: CGP-39; GP-39; hCGP-39

NCBI Description

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

Uniprot Description

CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family.

Protein type: Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; endoplasmic reticulum; extracellular exosome; extracellular region; extracellular space; perinuclear region of cytoplasm; proteinaceous extracellular matrix

Molecular Function: carbohydrate binding; chitin binding; chitinase activity; extracellular matrix structural constituent

Biological Process: activation of NF-kappaB-inducing kinase; apoptosis; carbohydrate metabolic process; cartilage development; cellular response to interleukin-1; cellular response to tumor necrosis factor; chitin catabolic process; inflammatory response; interleukin-8 secretion; lung development; neutrophil degranulation; positive regulation of angiogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein kinase B signaling; response to mechanical stimulus; response to tumor necrosis factor

Disease: Asthma-related Traits, Susceptibility To, 7; Schizophrenia