CD117 Recombinant Protein | CHGA recombinant protein
CD117, Recombinant, Human (c-Kit, KIT, Mast/stem Cell Growth Factor Receptor Kit, p145 c-kit, Piebald Trait Protein, PBT, Proto-oncogene c-Kit, SCFR, Tyrosine-protein Kinase Kit, v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog)
~95% (SDS-PAGE, Coomassie Brilliant Blue)
~95% (SDS-PAGE, Coomassie Brilliant Blue)
Dilution: Western Blot: Under reducing conditions SCFR migrates as a broad band between ~65 and 100kD on SDS-PAGE due to post-translational modifications. The unmodified SCFR polypeptide has a predicted monomeric molecular mass of 55.9kD. SCFR separates into a number of glycoforms with a pI between 4 and 7 on 2D PAGE due to post-translational modifications. The unmodified SCFR has a predicted pI of 6.1.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.
Subunit structure: Interacts with SCG3
By similarity.
Subcellular location: Cytoplasmic vesicle › secretory vesicle lumen
By similarity. Cytoplasmic vesicle › secretory vesicle membrane
By similarity. Secreted. Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions
By similarity.
Post-translational modification: Sulfated on tyrosine residues and/or contains sulfated glycans.O-glycosylated with core 1 or possibly core 8 glycans. Ref.16 Ref.20
Miscellaneous: Binds calcium with a low-affinity.
Sequence similarities: Belongs to the chromogranin/secretogranin protein family.
Research Articles on CHGA
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Product Notes
The CHGA chga (Catalog #AAA650137) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD117 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: Under reducing conditions SCFR migrates as a broad band between ~65 and 100kD on SDS-PAGE due to post-translational modifications. The unmodified SCFR polypeptide has a predicted monomeric molecular mass of 55.9kD. SCFR separates into a number of glycoforms with a pI between 4 and 7 on 2D PAGE due to post-translational modifications. The unmodified SCFR has a predicted pI of 6.1. Researchers should empirically determine the suitability of the CHGA chga for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD117, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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