CGA&CGB3 Heterodimer Recombinant Protein | CGA recombinant protein

Recombinant Human CGA&CGB3 Heterodimer Protein (C-DYKDDDDK,C-His)

Cat. Num. AAA2557274

• Gene Names: CGA; HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: CGA&CGB3 Heterodimer; Recombinant Human CGA&CGB3 Heterodimer Protein (C-DYKDDDDK; C-His); Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alpha; Thyroid-stimulating hormone alpha chain; TSH-alpha; CGA recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Ala25-Ser116 & Ser21-Gln165
• Sequence Length: 116

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-DYKDDDDK,C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CGA recombinant protein

Protein Construction: Recombinant Human CGA&CGB3 Heterodimer is produced by our mammalian expression system and the target gene encoding Ala25-Ser116&Ser21-Gln165 is expressed with a DYKDDDDK tag at the C-terminus, 6His tag at the C-terminus.

Background: Glycoprotein hormones alpha chain, also known as CGA, belongs to the glycoprotein hormones subunit alpha family. The subunit of CGA is a heterodimer consists of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. It has positive regulation of cell migration, cell proliferation and transcription from RNA polymerase II promoter and participates in the peptide hormone processing and signal transduction.

NCBI and Uniprot Product Information

• NCBI GI #: 546845
• NCBI GeneID: 1081
• UniProt Accession #: P01215; P0DN86
• Molecular Weight: Molecular Mass: 11.6 & 16.6kDa; Actual Protein Molecular Mass: 22 & 30-35kDa
• NCBI Official Full Name: thyroid-stimulating hormone alpha subunit
• NCBI Official Synonym Full Names: glycoprotein hormones, alpha polypeptide
• NCBI Official Symbol: CGA
• NCBI Official Synonym Symbols: HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA
• NCBI Protein Information: glycoprotein hormones alpha chain
• UniProt Protein Name: Glycoprotein hormones alpha chain
• Protein Family: Glycoprotein hormones
• UniProt Gene Name: CGA
• UniProt Synonym Gene Names: CG-alpha; FSH-alpha; LSH-alpha; TSH-alpha
• UniProt Entry Name: GLHA_HUMAN

NCBI Description

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

CGA: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6q12-q21

Cellular Component: extracellular region

Molecular Function: protein binding; hormone activity

Biological Process: cellular protein metabolic process; cell-cell signaling; peptide hormone processing; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of cell migration