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Mouse Complement Factor I ELISA Kit | CFI elisa kit

Mouse Complement Factor I ELISA Kit

Reactivity
Mouse
Synonyms
Complement Factor I; Mouse Complement Factor I ELISA Kit; CFI elisa kit
Ordering
For Research Use Only!
Reactivity
Mouse
Specificity
No significant cross-reactivity or interference between Mouse CFI and analogues was observed.
Samples
Human Serum, Plasma Or Tissue Homogenates Samples
Assay Type
Quantitative Sandwich
Detection Range
6.25ng/ml-200ng/ml
Sensitivity
1.0ng/ml.
Intra-assay Precision
Intra-assay CV (%) is less than 15%
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
Preparation and Storage
Store all reagents at 2-8 degree C
Related Product Information for CFI elisa kit
Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of CFHR3 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
67,298 Da
NCBI Official Full Name
complement factor I
NCBI Official Synonym Full Names
complement factor I
NCBI Official Symbol
Cfi
NCBI Protein Information
complement factor I; C3B/C4B inactivator
UniProt Protein Name
Complement factor I
Protein Family
UniProt Gene Name
Cfi
UniProt Synonym Gene Names
If
UniProt Entry Name
CFAI_RAT

NCBI Description

mouse homolog is a regulatory serine proteinase of the complement cascade that cleaves C3b and C4b and inactivates them [RGD, Feb 2006]

Uniprot Description

CFI: Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Defects in CFI are the cause of complement factor I deficiency (CFI deficiency). CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections. Belongs to the peptidase S1 family.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.45; Protease

Cellular Component: extracellular space; membrane; nucleus

Molecular Function: metal ion binding; serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; innate immune response; proteolysis; complement activation, classical pathway

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Product Notes

The Mouse CFI cfi (Catalog #AAA043388) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA043388 ELISA Kit recognizes Mouse CFI. It is sometimes possible for the material contained within the vial of "Complement Factor I, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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