Complement Factor H-Related 1 Recombinant Protein | CFHR1 recombinant protein

Recombinant Human Complement Factor H-Related 1 Protein

Cat. Num. AAA2556625

• Gene Names: CFHR1; CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Complement Factor H-Related 1; Recombinant Human Complement Factor H-Related 1 Protein; Complement Factor H-Related Protein 1; FHR-1; H Factor-Like Protein 1; H-Factor-Like 1; H36; CFHR1; CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2; CFHR1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, 2mM EDTA, pH 7.4.
• Sequence Length: 330

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Glu19-Arg330
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

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Related Product Information for CFHR1 recombinant protein

Protein Construction: Recombinant Human Complement Factor H-Related 1 is produced by our Mammalian expression system and the target gene encoding Glu19-Arg330 is expressed with a 6His tag at the C-terminus.

Background: Complement Factor H-Related 1 (CFHR1) is a 43 kDa secreted member of the factor H family of glycoproteins. The human Complement Factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1 (FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. FHR1 is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human FHR1 is 312 amino acids in length. It contains five, approximately 60 aa SCRs that basically constitute the entire molecule. FHR1 may play a role in complement regulation, lipid metabolism and lipoprotein complexes that bind PMNs to LPS.

NCBI and Uniprot Product Information

• NCBI GI #: 118442839
• NCBI GeneID: 3078
• NCBI Accession #: NP_002104.2
• NCBI GenBank Nucleotide #: NM_002113.2
• UniProt Accession #: Q03591; Q3B774; Q9UJ17; A8K465
• Molecular Weight: Molecular Mass: 36.8kDa; Actual Protein Molecular Mass: 39-43kDa
• NCBI Official Full Name: complement factor H-related protein 1
• NCBI Official Synonym Full Names: complement factor H related 1
• NCBI Official Symbol: CFHR1
• NCBI Official Synonym Symbols: CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P
• NCBI Protein Information: complement factor H-related protein 1
• UniProt Protein Name: Complement factor H-related protein 1
• Protein Family: Complement factor H-related protein
• UniProt Gene Name: CFHR1
• UniProt Synonym Gene Names: CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2; FHR-1; H-factor-like 1

NCBI Description

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]

Uniprot Description

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.