Centromere protein F / mitosin Blocking Peptide | CENPF blocking peptide
Centromere protein F / mitosin Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
Uniprot Description
CENPF: a nuclear matrix protein that assembles onto kinetochores at late G2. Is hyperphosphorylated during mitosis and rapidly degraded after mitosis. Involved in chromosome segregation during mitosis. Interacts with retinoblastoma protein (RB), CENP-E and BUBR1. Two alternatively spliced human isoforms have been described.
Protein type: Transcription, coactivator/corepressor; Nuclear envelope; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: axoneme; centrosome; chromatin; chromosome, pericentric region; cytoplasm; cytosol; kinetochore; midbody; nuclear envelope; nuclear matrix; nucleoplasm; nucleus; outer kinetochore of condensed chromosome; perinuclear region of cytoplasm; pronucleus; spindle; spindle pole
Molecular Function: chromatin binding; dynein binding; protein binding; protein C-terminus binding; protein homodimerization activity; transcription factor binding
Biological Process: cell differentiation; cell division; cell proliferation; chromosome segregation; kidney development; kinetochore assembly; metaphase plate congression; mitosis; mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; muscle development; negative regulation of transcription, DNA-dependent; protein transport; regulation of cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of striated muscle development; response to drug; sister chromatid cohesion; ventricular system development
Disease: Ciliary Dyskinesia, Primary, 31; Stromme Syndrome
Research Articles on CENPF
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Product Notes
The CENPF cenpf (Catalog #AAA425369) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The Centromere protein F / mitosin Immunizing Peptide reacts with Human, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GLESKGSENC KVQ. It is sometimes possible for the material contained within the vial of "Centromere protein F / mitosin, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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