ZFYVE20 cdna clone

ZFYVE20 cDNA Clone

Gene Names

RBSN; ZFYVE20; Rabenosyn-5

Synonyms

ZFYVE20; ZFYVE20 cDNA Clone; ZFYVE20 cdna clone

Ordering
Cat. Num. AAA1272914 For Research Use Only!

Sequence

ATGGCTTCTCTGGACGACCCAGGGGAAGTGAGGGAGGGCTTCCTCTGCCCTCTGTGCCTGAAGGATCTGCAGTCTTTCTATCAGCTTCACTCACATTACGAGGAAGAACACTCAGGGGAAGACCGTGATGTCAAAGGGCAAATTAAAAGTCTTGTCCAGAAGGCTAAAAAAGCAAAGGACAGGTTGTTGAAACGAGAAGGGGATGATCGAGCAGAGTCAGGGACCCAAGGATATGAGTCTTTCAGCTATGGAGGGGTTGATCCTTACATGTGGGAACCCCAGGAGCTTGGTGCTGTGAGAAGCCATCTTTCCGACTTCAAAAAACACCGAGCTGCTAGAATTGACCACTATGTTGTGGAAGTCAATAAACTAATAATCAGGTTAGAGAAGCTCACTGCATTTGACAGAACAAATACTGAGTCTGCAAAGATTCGAGCAATAGAAAAGTCTGTGGTGCCTTGGGTCAACGACCAGGATGTCCCTTTCTGTCCAGACTGTGGGAATAAGTTCAGCATCCGGAACCGCCGCCACCACTGCCGCCTCTGCGGGTCTATTATGTGCAAGAAGTGTATGGAGCTCATCAGCCTTCCCTTGGCAAACAAGCTCACCAGTGCCAGCAAGGAGTCCCTGAGCACCCACACCAGCCCCAGCCAGTCACCCAACAGTGTCCATGGCTCCCGCCGAGGCAGCATCAGCAGCATGAGCAGTGTCAGCTCGGTCCTGGATGAGAAGGACGATGACCGGATCCGCTGCTGTACACACTGCAAGGACACGCTGCTCAAGAGAGAGCAGCAGATTGATGAGAAGGAGCACACACCTGACATCGTGAAGCTCTACGAGAAATTACGACTTTGCATGGAGAAAGTTGACCAGAAAGCTCCAGAATACATCAGGATGGCAGCATCATTAAATGCTGGGGAGACAACCTACAGTCTGGAACATGCCAGTGACCTTCGAGTGGAAGTGCAGAAAGTGTATGAGCTGATAGACGCTTTAAGTAAGAAGATCTTAACCTTGGGCTTGAACCAGGACCCTCCACCACATCCAAGCAATTTGCGGCTGCAGAGAATGATCAGATACTCAGCTACACTTTTTGTGCAGGAAAAGTTGCTTGGTTTGATGTCACTGCCAACCAAAGAACAGTTTGAGGAACTGAAAAAGAAAAGGAAGGAGGAAATGGAGAGGAAGAGGGCCGTGGAGAGACAAGCTGCCCTGGAGTCCCAGCGAAGGCTTGAGGAAAGGCAGAGTGGCCTGGCTTCTCGAGCGGCCAACGGGGAGGTGGCATCTCTCCGCAGGGGCCCTGCCCCCTTGAGAAAGGCTGAGGGCTGGCTCCCACTGTCAGGAGGTCAGGGGCAGAGTGAGGACTCAGACCCGCTCCTCCAGCAGATCCACAACATCACATCATTCATCAGGCAGGCCAAGGCCGCGGGCCGCATGGATGAAGTGCGCACTCTGCAGGAGAACCTGCGGCAGCTGCAGGACGAGTATGACCAGCAGCAGACAGAGAAGGCCATCGAGCTGTCCCGGAGGCAGGCTGAGGAGGAGGACCTGCAGCGGGAACAGCTGCAGATGTTGCGTGAACGGGAGTTGGAACGAGAAAGGGAGCAGTTTCGGGTGGCATCCCTGCACACACGGACTCGGTCCCTGGACTTCAGAGAAATCGGCCCTTTTCAGCTGGAGCCCAGCAGAGAGCCTCGCACCCACCTTGCTTATGCTTTGGATCTAGGCTCTTCCCCAGTTCCAAGCAGCACAGCTCCCAAGACCCCTTCACTTAGCTCAACTCAACCCACCAGAGTGTGGTCTGGGCCCCCAGCCGTTGGCCAGGAGCGCTTACCCCAGAGCAGCATGCCACAGCAACATGAGGGGCCCTCCTTAAACCCCTTTGATGAGGAAGACCTCTCCAGCCCCATGGAAGAGGCCACTACTGGTCCTCCTGCTGCAGGGGTTTCCTTAGACCCTTCAGCCCGCATCCTGAAAGAGTACAATCCTTTCGAGGAAGAGGACGAGGAGGAGGAAGCAGTGGCAGGGAATCCATTCATTCAGCCAGACAGCCCAGCTCCTAACCCCTTCAGTGAGGAAGACGAACATCCCCAGCAGAGGCTCTCAAGCCCTCTGGTTCCTGGTAACCCCTTTGAGGAACCCACCTGTATCAACCCCTTTGAGATGGACAGTGACAGTGGGCCAGAGGCTGAGGAGCCCATAGAGGAAGAGCTCCTCCTGCAGCAGATCGATAACATCAAGGCATACATCTTTGATGCCAAGCAGTGCGGCCGCCTGGATGAGGTAGAGGTGCTGACAGAGAATCTGCGGGAGCTGAAGCACACCCTGGCCAAGCAGAAGGGGGGCACTGACTGA

Sequence Length

2355

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

NCBI and Uniprot Product Information

NCBI GI #

115528538

NCBI GeneID

64145

Molecular Weight

23,794 Da

NCBI Official Full Name

Homo sapiens zinc finger, FYVE domain containing 20, mRNA

NCBI Official Synonym Full Names

rabenosyn, RAB effector

NCBI Official Symbol

RBSN

NCBI Official Synonym Symbols

ZFYVE20; Rabenosyn-5

NCBI Protein Information

rabenosyn-5

UniProt Protein Name

Rabenosyn-5

UniProt Gene Name

RBSN

UniProt Entry Name

RBNS5_HUMAN

NCBI Description

This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Description

ZFYVE20: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).

Protein type: Adaptor/scaffold; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: endosome membrane; intracellular membrane-bound organelle

Molecular Function: protein binding; Rab GTPase binding

Biological Process: blood coagulation; endocytosis; endosomal vesicle fusion; Golgi to endosome transport; Golgi to vacuole transport; vacuole inheritance

Research Articles on ZFYVE20

1. A functional defect in the endocytic pathway resulting from a point mutation in Rabenosyn-5 leads to severe multi-organ disorder.

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Product Notes

The ZFYVE20 rbsn (Catalog #AAA1272914) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTTCTC TGGACGACCC AGGGGAAGTG AGGGAGGGCT TCCTCTGCCC TCTGTGCCTG AAGGATCTGC AGTCTTTCTA TCAGCTTCAC TCACATTACG AGGAAGAACA CTCAGGGGAA GACCGTGATG TCAAAGGGCA AATTAAAAGT CTTGTCCAGA AGGCTAAAAA AGCAAAGGAC AGGTTGTTGA AACGAGAAGG GGATGATCGA GCAGAGTCAG GGACCCAAGG ATATGAGTCT TTCAGCTATG GAGGGGTTGA TCCTTACATG TGGGAACCCC AGGAGCTTGG TGCTGTGAGA AGCCATCTTT CCGACTTCAA AAAACACCGA GCTGCTAGAA TTGACCACTA TGTTGTGGAA GTCAATAAAC TAATAATCAG GTTAGAGAAG CTCACTGCAT TTGACAGAAC AAATACTGAG TCTGCAAAGA TTCGAGCAAT AGAAAAGTCT GTGGTGCCTT GGGTCAACGA CCAGGATGTC CCTTTCTGTC CAGACTGTGG GAATAAGTTC AGCATCCGGA ACCGCCGCCA CCACTGCCGC CTCTGCGGGT CTATTATGTG CAAGAAGTGT ATGGAGCTCA TCAGCCTTCC CTTGGCAAAC AAGCTCACCA GTGCCAGCAA GGAGTCCCTG AGCACCCACA CCAGCCCCAG CCAGTCACCC AACAGTGTCC ATGGCTCCCG CCGAGGCAGC ATCAGCAGCA TGAGCAGTGT CAGCTCGGTC CTGGATGAGA AGGACGATGA CCGGATCCGC TGCTGTACAC ACTGCAAGGA CACGCTGCTC AAGAGAGAGC AGCAGATTGA TGAGAAGGAG CACACACCTG ACATCGTGAA GCTCTACGAG AAATTACGAC TTTGCATGGA GAAAGTTGAC CAGAAAGCTC CAGAATACAT CAGGATGGCA GCATCATTAA ATGCTGGGGA GACAACCTAC AGTCTGGAAC ATGCCAGTGA CCTTCGAGTG GAAGTGCAGA AAGTGTATGA GCTGATAGAC GCTTTAAGTA AGAAGATCTT AACCTTGGGC TTGAACCAGG ACCCTCCACC ACATCCAAGC AATTTGCGGC TGCAGAGAAT GATCAGATAC TCAGCTACAC TTTTTGTGCA GGAAAAGTTG CTTGGTTTGA TGTCACTGCC AACCAAAGAA CAGTTTGAGG AACTGAAAAA GAAAAGGAAG GAGGAAATGG AGAGGAAGAG GGCCGTGGAG AGACAAGCTG CCCTGGAGTC CCAGCGAAGG CTTGAGGAAA GGCAGAGTGG CCTGGCTTCT CGAGCGGCCA ACGGGGAGGT GGCATCTCTC CGCAGGGGCC CTGCCCCCTT GAGAAAGGCT GAGGGCTGGC TCCCACTGTC AGGAGGTCAG GGGCAGAGTG AGGACTCAGA CCCGCTCCTC CAGCAGATCC ACAACATCAC ATCATTCATC AGGCAGGCCA AGGCCGCGGG CCGCATGGAT GAAGTGCGCA CTCTGCAGGA GAACCTGCGG CAGCTGCAGG ACGAGTATGA CCAGCAGCAG ACAGAGAAGG CCATCGAGCT GTCCCGGAGG CAGGCTGAGG AGGAGGACCT GCAGCGGGAA CAGCTGCAGA TGTTGCGTGA ACGGGAGTTG GAACGAGAAA GGGAGCAGTT TCGGGTGGCA TCCCTGCACA CACGGACTCG GTCCCTGGAC TTCAGAGAAA TCGGCCCTTT TCAGCTGGAG CCCAGCAGAG AGCCTCGCAC CCACCTTGCT TATGCTTTGG ATCTAGGCTC TTCCCCAGTT CCAAGCAGCA CAGCTCCCAA GACCCCTTCA CTTAGCTCAA CTCAACCCAC CAGAGTGTGG TCTGGGCCCC CAGCCGTTGG CCAGGAGCGC TTACCCCAGA GCAGCATGCC ACAGCAACAT GAGGGGCCCT CCTTAAACCC CTTTGATGAG GAAGACCTCT CCAGCCCCAT GGAAGAGGCC ACTACTGGTC CTCCTGCTGC AGGGGTTTCC TTAGACCCTT CAGCCCGCAT CCTGAAAGAG TACAATCCTT TCGAGGAAGA GGACGAGGAG GAGGAAGCAG TGGCAGGGAA TCCATTCATT CAGCCAGACA GCCCAGCTCC TAACCCCTTC AGTGAGGAAG ACGAACATCC CCAGCAGAGG CTCTCAAGCC CTCTGGTTCC TGGTAACCCC TTTGAGGAAC CCACCTGTAT CAACCCCTTT GAGATGGACA GTGACAGTGG GCCAGAGGCT GAGGAGCCCA TAGAGGAAGA GCTCCTCCTG CAGCAGATCG ATAACATCAA GGCATACATC TTTGATGCCA AGCAGTGCGG CCGCCTGGAT GAGGTAGAGG TGCTGACAGA GAATCTGCGG GAGCTGAAGC ACACCCTGGC CAAGCAGAAG GGGGGCACTG ACTGA. It is sometimes possible for the material contained within the vial of "ZFYVE20, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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ZFYVE20 cdna clone