ZEB2 cdna clone

ZEB2 cDNA Clone

Gene Names

ZEB2; SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1

Synonyms

ZEB2; ZEB2 cDNA Clone; ZEB2 cdna clone

Ordering
Cat. Num. AAA1267079 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Sequence

ATGAAGCAGCCGATCATGGCGGATGGCCCCCGGTGCAAGAGGCGCAAACAAGCCAATCCCAGGAGGAAAAACGTGGTGAACTATGACAATGTAGTGGACACAGGTTCTGAAACAGATGAGGAAGACAAGCTTCATATTGCTGAGGATGACGGTATTGCCAACCCTCTGGACCAGGAGACGAGTCCAGCTAGTGTGCCCAACCATGAGTCCTCCCCACACGTGAGCCAAGCTCTGTTGCCAAGAGAGGAAGAGGAAGATGAAATAAGGGAGGGTGGAGTGGAACACCCCTGGCACAACAACGAGATTCTACAAGCCTCTGTAGATGGTCCAGAAGAAATGAAGGAAGACTATGACACTATGGGGCCAGAAGCCACGATCCAGACCGCAATTAACAATGGTACAGTGAAGAATGCAAATTGCACATCAGATTTTGAGGAATACTTTGCCAAAAGAAAACTGGAGGAACGCGATGGTCATGCAGTCAGCATCGAGGAGTACCTTCAGCGCAGTGACACAGCCATTATTTACCCAGAAGCCCCTGAGGAGCTGTCTCGCCTTGGCACGCCAGAGGCCAATGGGCAAGAAGAAAATGACCTGCCACCTGGAACTCCAGATGCTTTTGCCCAACTGCTGACCTGCCCCTACTGCGACCGGGGCTACAAGCGCTTGACATCACTGAAGGAGCACATCAAGTACCGCCACGAGAAGAATGAAGAGAACTTTTCCTGCCCTCTCTGTAGCTACACGTTTGCCTACCGCACCCAGCTCGAGCGGCATATGGTGACACACAAGCCAGGGACAGATCAGCACCAAATGCTAACCCAAGGAGCAGGTAATCGCAAGTTCAAATGCACAGAGTGTGGCAAGGCCTTCAAATATAAACACCATCTGAAAGAACACCTGCGAATTCACAGTGGTGAAAAACCTTACGAGTGCCCAAACTGCAAGAAACGTTTCTCCCATTCTGGTTCCTACAGTTCGCACATCAGCAGCAAGAAATGTATTGGTTTAATCTCTGTAAATGGCCGAATGAGAAACAATATCAAGACGGGTTCTTCCCCTAATTCTGTTTCTTCTTCTCCTACTAATTCAGCCATTACCCAGTTAAGAAACAAGTTGGAGAATGGAAAACCACTTAGTATGTCTGAACAGACAGGCTTACTTAAAATTAAAACAGAACCACTAGACTTCAATGACTATAAAGTTCTTATGGCTACACACGGGTTTAGTGGCACTAGTCCCTTTATGAATGGTGGGCTTGGAGCCACCAGCCCTTTAGGAGTTCATCCATCTGCTCAGAGTCCAATGCAGCACTTAGGTGTAGGGATGGAAGCCCCTTTACTTGGGTTTCCCACCATGAATAGTAATTTAAGTGAGGTACAAAAGGTTCTACAGATTGTGGACAATACTGTTTCCAGGCAAAAAATGGACTGCAAGGCTGAAGAAATTTCAAAGTTGAAAGGTTATCACATGAAGGATCCATGCTCTCAACCTGAGGAACAAGGAGTTACTTCTCCTAATATTCCGCCTGTCGGTCTTCCGGTAGTGAGTCATAATGGTGCCACTAAAAGTATTATTGACTATACGTTGGAAAAAGTCAATGAAGCCAAAGCTTGCCTCCAGAGCTTGACTACTGACTCAAGGAGACAGATCAGTAATATAAAGAAAGAGAAGCTACGTACTTTAATAGATTTGGTCACTGATGACAAAATGATTGAGAACCACAACATATCCACTCCATTTTCATGCCAGTTCTGTAAAGAAAGTTTTCCTGGCCCCATCCCTTTGCATCAGCATGAACGTTACCTTTGTAAGATGAATGAAGAGATCAAGGCGGTCCTGCAGCCTCATGAAAACATAGTCCCCAACAAAGCCGGAGTTTTTGTTGATAATAAAGCCCTCCTCTTGTCATCTGTACTTTCTGAGAAAGGAATGACAAGCCCCATCAACCCATACAAGGACCACATGTCTGTACTCAAAGCATACTATGCTATGAACATGGAGCCCAACTCCGATGAACTGCTGAAAATTTCCATTGCTGTGGGCCTTCCTCAGGAATTTGTGAAGGAATGGTTTGAACAACGAAAAGTCTACCAGTACTCAAATTCCAGGTCCCCATCCCTGGAAAGAAGCTCCAAGCCGTTAGCTCCCAACAGTAACCCTCCCACAAAAGACTCTTTATTACCCAGGTCTCCTGTAAAACCTATGGACTCCATAACATCACCATCTATAGCAGAACTCCACAACAGTGTTACGAATTGTGATCCTCCTCTCAGGCTAACAAAACCTTCCCATTTTACCAATATTAAACCAGTTGAAAAATTGGACCACTCCAGGAGTAATACTCCTTCTCCCTTAAATCTTTCCTCCACATCTTCTAAAAACTCCCACAGTAGTTCATACACTCCAAACAGCTTCTCTTCTGAGGAGCTCCAGGCTGAGCCTTTAGACTTGTCATTACCAAAACAAATGAAAGAACCCAAAAGTATTATAGCCACAAAGAACAAAACAAAAGCTAGTAGCATCAGTTTAGATCATAACAGTGTTTCTTCCTCATCTGAAAACTCAGATGAGCCTCTGAACTTGACTTTTATCAAGAAGGAATTTTCAAATTCAAATAATCTGGACAACAAAAGCACTAACCCAGTGTTCAGCATGAACCCATTTAGTGCCAAACCTTTATACACAGCTCTTCCACCTCAAAGCGCATTTCCCCCTGCTACTTTCATGCCACCAGTCCAGACCAGTATTCCTGGGCTACGACCATACCCAGGACTGGATCAGATGAGCTTCCTACCACATATGGCCTACACCTACCCAACTGGAGCAGCTACTTTTGCTGATATGCAGCAAAGGAGAAAGTACCAGCGGAAACAAGGATTTCAGGGAGAATTGCTTGATGGAGCACAAGACTACATGTCAGGCCTAGATGATATGACAGACTCCGACTCCTGTCTGTCTCGCAAAAAGATCAAGAAGACAGAGAGTGGCATGTATGCATGTGACTTATGTGACAAGACATTCCAGAAAAGCAGTTCCCTTCTGCGACATAAATACGAACACACAGGAAAAAGACCACATCAGTGTCAGATTTGTAAGAAAGCGTTTAAACACAAGCACCACCTTATCGAGCACTCAAGGCTTCACTCGGGCGAGAAGCCCTATCAGTGTGATAAATGTGGCAAGCGCTTCTCACACTCGGGCTCGTACTCGCAGCACATGAATCACAGGTATTCCTACTGCAAGCGGGAGGCGGAGGAGCGGGAAGCGGCGGAGCGCGAGGCGCGCGAGAAAGGGCACTTGGAACCCACCGAGCTGCTGATGAACCGGGCTTACTTGCAGAGCATTACCCCTCAGGGGTACTCTGACTCGGAGGAGAGGGAGAGTATGCCGAGGGATGGCGAGAGCGAGAAGGAGCACGAGAAAGAAGGCGAGGATGGCTACGGGAAGCTGGGCAGACAGGATGGCGACGAGGAGTTCGAGGAGGAAGAGGAAGAAAGTGAAAATAAAAGTATGGATACGGATCCCGAAACGATACGAGATGAAGAAGAGACTGGAGATCACTCCATGGACGATAGTTCGGAGGATGGGAAAATGGAAACCAAATCAGACCACGAGGAAGACAATATGGAAGATGGCATGTAA

Sequence Length

3645

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

117558785

NCBI GeneID

9839

Molecular Weight

133,806 Da

NCBI Official Full Name

Homo sapiens zinc finger E-box binding homeobox 2, mRNA

NCBI Official Synonym Full Names

zinc finger E-box binding homeobox 2

NCBI Official Symbol

ZEB2

NCBI Official Synonym Symbols

SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1

NCBI Protein Information

zinc finger E-box-binding homeobox 2

UniProt Protein Name

Zinc finger E-box-binding homeobox 2

Protein Family

Zinc finger E-box-binding homeobox

UniProt Gene Name

ZEB2

UniProt Synonym Gene Names

KIAA0569; SIP1; ZFHX1B; ZFX1B; SMADIP1

UniProt Entry Name

ZEB2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Uniprot Description

ZEB2: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS); also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Protein type: Transcription, coactivator/corepressor; Motility/polarity/chemotaxis; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter; pigmentation during development; positive regulation of melanin biosynthetic process; positive regulation of melanocyte differentiation; positive regulation of transcription from RNA polymerase II promoter

Disease: Mowat-wilson Syndrome

Research Articles on ZEB2

1. restoration of expression of ZEB2 weakened miR-154-mediated suppression of tumor progression. miR-154 functions as a tumor suppressor in HCC by suppressing ZEB2, suggesting that miR-154 may serve as a potential target for HCC.

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Product Notes

The ZEB2 zeb2 (Catalog #AAA1267079) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAGCAGC CGATCATGGC GGATGGCCCC CGGTGCAAGA GGCGCAAACA AGCCAATCCC AGGAGGAAAA ACGTGGTGAA CTATGACAAT GTAGTGGACA CAGGTTCTGA AACAGATGAG GAAGACAAGC TTCATATTGC TGAGGATGAC GGTATTGCCA ACCCTCTGGA CCAGGAGACG AGTCCAGCTA GTGTGCCCAA CCATGAGTCC TCCCCACACG TGAGCCAAGC TCTGTTGCCA AGAGAGGAAG AGGAAGATGA AATAAGGGAG GGTGGAGTGG AACACCCCTG GCACAACAAC GAGATTCTAC AAGCCTCTGT AGATGGTCCA GAAGAAATGA AGGAAGACTA TGACACTATG GGGCCAGAAG CCACGATCCA GACCGCAATT AACAATGGTA CAGTGAAGAA TGCAAATTGC ACATCAGATT TTGAGGAATA CTTTGCCAAA AGAAAACTGG AGGAACGCGA TGGTCATGCA GTCAGCATCG AGGAGTACCT TCAGCGCAGT GACACAGCCA TTATTTACCC AGAAGCCCCT GAGGAGCTGT CTCGCCTTGG CACGCCAGAG GCCAATGGGC AAGAAGAAAA TGACCTGCCA CCTGGAACTC CAGATGCTTT TGCCCAACTG CTGACCTGCC CCTACTGCGA CCGGGGCTAC AAGCGCTTGA CATCACTGAA GGAGCACATC AAGTACCGCC ACGAGAAGAA TGAAGAGAAC TTTTCCTGCC CTCTCTGTAG CTACACGTTT GCCTACCGCA CCCAGCTCGA GCGGCATATG GTGACACACA AGCCAGGGAC AGATCAGCAC CAAATGCTAA CCCAAGGAGC AGGTAATCGC AAGTTCAAAT GCACAGAGTG TGGCAAGGCC TTCAAATATA AACACCATCT GAAAGAACAC CTGCGAATTC ACAGTGGTGA AAAACCTTAC GAGTGCCCAA ACTGCAAGAA ACGTTTCTCC CATTCTGGTT CCTACAGTTC GCACATCAGC AGCAAGAAAT GTATTGGTTT AATCTCTGTA AATGGCCGAA TGAGAAACAA TATCAAGACG GGTTCTTCCC CTAATTCTGT TTCTTCTTCT CCTACTAATT CAGCCATTAC CCAGTTAAGA AACAAGTTGG AGAATGGAAA ACCACTTAGT ATGTCTGAAC AGACAGGCTT ACTTAAAATT AAAACAGAAC CACTAGACTT CAATGACTAT AAAGTTCTTA TGGCTACACA CGGGTTTAGT GGCACTAGTC CCTTTATGAA TGGTGGGCTT GGAGCCACCA GCCCTTTAGG AGTTCATCCA TCTGCTCAGA GTCCAATGCA GCACTTAGGT GTAGGGATGG AAGCCCCTTT ACTTGGGTTT CCCACCATGA ATAGTAATTT AAGTGAGGTA CAAAAGGTTC TACAGATTGT GGACAATACT GTTTCCAGGC AAAAAATGGA CTGCAAGGCT GAAGAAATTT CAAAGTTGAA AGGTTATCAC ATGAAGGATC CATGCTCTCA ACCTGAGGAA CAAGGAGTTA CTTCTCCTAA TATTCCGCCT GTCGGTCTTC CGGTAGTGAG TCATAATGGT GCCACTAAAA GTATTATTGA CTATACGTTG GAAAAAGTCA ATGAAGCCAA AGCTTGCCTC CAGAGCTTGA CTACTGACTC AAGGAGACAG ATCAGTAATA TAAAGAAAGA GAAGCTACGT ACTTTAATAG ATTTGGTCAC TGATGACAAA ATGATTGAGA ACCACAACAT ATCCACTCCA TTTTCATGCC AGTTCTGTAA AGAAAGTTTT CCTGGCCCCA TCCCTTTGCA TCAGCATGAA CGTTACCTTT GTAAGATGAA TGAAGAGATC AAGGCGGTCC TGCAGCCTCA TGAAAACATA GTCCCCAACA AAGCCGGAGT TTTTGTTGAT AATAAAGCCC TCCTCTTGTC ATCTGTACTT TCTGAGAAAG GAATGACAAG CCCCATCAAC CCATACAAGG ACCACATGTC TGTACTCAAA GCATACTATG CTATGAACAT GGAGCCCAAC TCCGATGAAC TGCTGAAAAT TTCCATTGCT GTGGGCCTTC CTCAGGAATT TGTGAAGGAA TGGTTTGAAC AACGAAAAGT CTACCAGTAC TCAAATTCCA GGTCCCCATC CCTGGAAAGA AGCTCCAAGC CGTTAGCTCC CAACAGTAAC CCTCCCACAA AAGACTCTTT ATTACCCAGG TCTCCTGTAA AACCTATGGA CTCCATAACA TCACCATCTA TAGCAGAACT CCACAACAGT GTTACGAATT GTGATCCTCC TCTCAGGCTA ACAAAACCTT CCCATTTTAC CAATATTAAA CCAGTTGAAA AATTGGACCA CTCCAGGAGT AATACTCCTT CTCCCTTAAA TCTTTCCTCC ACATCTTCTA AAAACTCCCA CAGTAGTTCA TACACTCCAA ACAGCTTCTC TTCTGAGGAG CTCCAGGCTG AGCCTTTAGA CTTGTCATTA CCAAAACAAA TGAAAGAACC CAAAAGTATT ATAGCCACAA AGAACAAAAC AAAAGCTAGT AGCATCAGTT TAGATCATAA CAGTGTTTCT TCCTCATCTG AAAACTCAGA TGAGCCTCTG AACTTGACTT TTATCAAGAA GGAATTTTCA AATTCAAATA ATCTGGACAA CAAAAGCACT AACCCAGTGT TCAGCATGAA CCCATTTAGT GCCAAACCTT TATACACAGC TCTTCCACCT CAAAGCGCAT TTCCCCCTGC TACTTTCATG CCACCAGTCC AGACCAGTAT TCCTGGGCTA CGACCATACC CAGGACTGGA TCAGATGAGC TTCCTACCAC ATATGGCCTA CACCTACCCA ACTGGAGCAG CTACTTTTGC TGATATGCAG CAAAGGAGAA AGTACCAGCG GAAACAAGGA TTTCAGGGAG AATTGCTTGA TGGAGCACAA GACTACATGT CAGGCCTAGA TGATATGACA GACTCCGACT CCTGTCTGTC TCGCAAAAAG ATCAAGAAGA CAGAGAGTGG CATGTATGCA TGTGACTTAT GTGACAAGAC ATTCCAGAAA AGCAGTTCCC TTCTGCGACA TAAATACGAA CACACAGGAA AAAGACCACA TCAGTGTCAG ATTTGTAAGA AAGCGTTTAA ACACAAGCAC CACCTTATCG AGCACTCAAG GCTTCACTCG GGCGAGAAGC CCTATCAGTG TGATAAATGT GGCAAGCGCT TCTCACACTC GGGCTCGTAC TCGCAGCACA TGAATCACAG GTATTCCTAC TGCAAGCGGG AGGCGGAGGA GCGGGAAGCG GCGGAGCGCG AGGCGCGCGA GAAAGGGCAC TTGGAACCCA CCGAGCTGCT GATGAACCGG GCTTACTTGC AGAGCATTAC CCCTCAGGGG TACTCTGACT CGGAGGAGAG GGAGAGTATG CCGAGGGATG GCGAGAGCGA GAAGGAGCAC GAGAAAGAAG GCGAGGATGG CTACGGGAAG CTGGGCAGAC AGGATGGCGA CGAGGAGTTC GAGGAGGAAG AGGAAGAAAG TGAAAATAAA AGTATGGATA CGGATCCCGA AACGATACGA GATGAAGAAG AGACTGGAGA TCACTCCATG GACGATAGTT CGGAGGATGG GAAAATGGAA ACCAAATCAG ACCACGAGGA AGACAATATG GAAGATGGCA TGTAA. It is sometimes possible for the material contained within the vial of "ZEB2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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