ZAP70 cdna clone
ZAP70 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ZAP70: a tyrosine kinase of the Syk family. Associates with the T-cell antigen receptor zeta-chain after TCR stimulation. Phosphorylated by Src-family kinases following antigen receptor activation. Plays a role in lymphocyte activation.
Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; Protein kinase, TK; TK group; Syk family
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; lipid raft; plasma membrane; T cell receptor complex
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding
Biological Process: adaptive immune response; B cell activation; B cell receptor signaling pathway; immune response; inflammatory response; innate immune response; macrophage activation during immune response; neutrophil activation during immune response; peptidyl-tyrosine phosphorylation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; positive regulation of T cell differentiation; positive thymic T cell selection; protein amino acid phosphorylation; T cell activation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Autoimmune Disease, Multisystem, Infantile-onset, 2; Selective T-cell Defect
Research Articles on ZAP70
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Product Notes
The ZAP70 zap70 (Catalog #AAA1265997) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcgcttgg ggccgcgctg gaagggcgag gccctggagc aggccatcat cagccaggcc ccgcaggtgg agaagctcat tgctacgacg gcccacgagc ggatgccctg gtaccacagc agcctgacgc gtgaggaggc cgagcgcaaa ctttactctg gggcgcagac cgacggcaag ttcctgctga ggccgcggaa ggagcagggc acatacgccc tgtccctcat ctatgggaag acggtgtacc actacctcat cagccaagac aaggcgggca agtactgcat tcccgagggc accaagtttg acacgctctg gcagctggtg gagtatctga agctgaaggc ggacgggctc atctactgcc tgaaggaggc ctgccccaac agcagtgcca gcaacgcctc aggggctgct gctcccacac tcccagccca cccatccacg ttgactcatc ctcagagacg aatcgacacc ctcaactcag atggatacac ccctgagcca gcacgcataa cgtccccaga caaaccgcgg ccgatgccca tggacacgag cgtgtatgag agcccctaca gcgacccaga ggagctcaag gacaagaagc tcttcctgaa gcgcgataac ctcctcatag ctgacattga acttggctgc ggcaactttg gctcagtgcg ccagggcgtg taccgcatgc gcaagaagca gatcgacgtg gccatcaagg tgctgaagca gggcacggag aaggcagaca cggaagagat gatgcgcgag gcgcagatca tgcaccagct ggacaacccc tacatcgtgc ggctcattgg cgtctgccag gccgaggccc tcatgctggt catggagatg gctgggggcg ggccgctgca caagttcctg gtcggcaaga gggaggagat ccctgtgagc aatgtggccg agctgctgca ccaggtgtcc atggggatga agtacctgga ggagaagaac tttgtgcacc gtgacctggc ggcccgcaac gtcctgctgg ttaaccggca ctacgccaag atcagcgact ttggcctctc caaagcactg ggtgccgacg acagctacta cactgcccgc tcagcaggga agtggccgct caagtggtac gcacccgaat gcatcaactt ccgcaagttc tccagccgca gcgatgtctg gagctatggg gtcaccatgt gggaggcctt gtcctacggc cagaagccct acaagaagat gaaagggccg gaggtcatgg ccttcatcga gcagggcaag cggatggagt gcccaccaga gtgtccaccc gaactgtacg cactcatgag tgactgctgg atctacaagt gggaggatcg ccccgacttc ctgaccgtgg agcagcgcat gcgagcctgt tactacagcc tggccagcaa ggtggaaggg cccccaggca gcacacagaa ggctgaggct gcctgtgcct ga. It is sometimes possible for the material contained within the vial of "ZAP70, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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