VHLL cdna clone
VHLL cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010]
Uniprot Description
VHLL: Functions as a dominant-negative VHL to serve as a protector of HIFalpha.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: nucleus; VCB complex
Molecular Function: protein binding
Biological Process: protein ubiquitination
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Product Notes
The VHLL vhll (Catalog #AAA1266427) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgccctgga gagcggggaa cggggtgggt ttagaggccc aggcgggcac ccaggaggca ggcccagaag agtactgcca ggaagagttg ggcgccgagg aggagatggc agccagagca gcatggcctg tgctgcgctc tgtgaactca cgcgagctct cccggatcat catctgcaat cacagcccac gaatcgtgct gcctgtgtgg ctcaactact atggcaagct gctgccctac ctgacgctgc tgcccggcag ggacttccgc atccacaact tccgaagcca cccttggctc ttcagagatg caaggacaca tgataagctt ctggttaacc aaactgaatt gtttgtgcca tcttccaatg ttaatggaca gcctgttttt gccaacatca cactgcagtg tataccctga. It is sometimes possible for the material contained within the vial of "VHLL, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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