USP4 cdna clone
USP4 cDNA Clone
Gene Names
USP4; UNP; Unph
Synonyms
USP4; USP4 cDNA Clone; USP4 cdna clone
Sequence
ATGGCGGAAGGTGGAGGCTGCCGTGAGCGACCGGATGCGGAGACTCAGAAGTCCGAGCTTGGACCCTTAATGAGGACCACACTCCAACGCGGGGCGCAGTGGTATCTTATTGACAGCCGGTGGTTCAAGCAGTGGAAGAAGTATGTGGGCTTTGACAGCTGGGACATGTACAATGTGGGTGAACATAACCTATTTCCTGGCCCAATAGACAACTCTGGGCTATTTTCAGATCCTGAGAGTCAGACCTTGAAAGAACACTTAATTGATGAATTGGACTATGTATTGGTCCCTACCGAGGCGTGGAATAAACTACTAAACTGGTACGGCTGTGTAGAAGGCCAGCAACCCATCGTCAGAAAAGTTGTGGAGCATGGCCTGTTTGTCAAGCACTGCAAAGTCGAGGTGTATTTGCTGGAACTGAAGCTCTGTGAGAACAGTGACCCCACCAATGTGCTGAGTTGCCATTTCAGCAAGGCAGACACCATTGCAACCATCGAGAAAGAGATGCGGAAGCTATTCAACATCCCTGCGGAGCGTGAAACACGGCTCTGGAACAAATACATGAGCAACACCTACGAGCAGTTGAGCAAGCTAGACAACACTGTCCAGGATGCTGGGCTATACCAGGGTCAGGTGCTAGTAATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTTGCAGTCAAAATCAAGCACTGCGCCTAGCAGAAATTTTACTACCTCTCCAAAATCATCAGCAAGTCCCTATTCCTCAGTGTCTGCCTCTCTCATTGCAAATGGTGATAGCACTAGCACCTGTGGGATGCACAGTTCCGGTGTCAGCAGGGGTGGATCTGGCTTTTCTGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATATACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAACTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGACTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCCTCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTGTGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGGTTGCCCAGAATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCCACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGTTCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTTAAACCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTACTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGCATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTTAACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAGCCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAACAGCTGACATAAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAACTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGAGACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGTGAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGAGTTTGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACACTGCATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTTTGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAA
Sequence Length
2892
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
35,661 Da
NCBI Official Full Name
Homo sapiens ubiquitin specific peptidase 4 (proto-oncogene), mRNA
NCBI Official Synonym Full Names
ubiquitin specific peptidase 4
NCBI Official Symbol
USP4
NCBI Official Synonym Symbols
UNP; Unph
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 4
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 4
UniProt Gene Name
USP4
UniProt Synonym Gene Names
UNP; UNPH
UniProt Entry Name
UBP4_HUMAN
NCBI Description
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
USP4: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER. Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with RB1, RBL1 and RBL2. Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung. Expressed in the hippocampal neurons. Belongs to the peptidase C19 family. USP4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Protease; Ubiquitin-specific protease; EC 3.4.19.12; Oncoprotein
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cytoplasm; lysosome; nucleus; plasma membrane
Molecular Function: adenosine receptor binding; identical protein binding; protein binding; ubiquitin-specific protease activity
Biological Process: assembly of spliceosomal tri-snRNP; negative regulation of protein ubiquitination; protein deubiquitination; regulation of protein stability
Research Articles on USP4
Similar Products
Product Notes
The USP4 usp4 (Catalog #AAA1268217) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGAAG GTGGAGGCTG CCGTGAGCGA CCGGATGCGG AGACTCAGAA GTCCGAGCTT GGACCCTTAA TGAGGACCAC ACTCCAACGC GGGGCGCAGT GGTATCTTAT TGACAGCCGG TGGTTCAAGC AGTGGAAGAA GTATGTGGGC TTTGACAGCT GGGACATGTA CAATGTGGGT GAACATAACC TATTTCCTGG CCCAATAGAC AACTCTGGGC TATTTTCAGA TCCTGAGAGT CAGACCTTGA AAGAACACTT AATTGATGAA TTGGACTATG TATTGGTCCC TACCGAGGCG TGGAATAAAC TACTAAACTG GTACGGCTGT GTAGAAGGCC AGCAACCCAT CGTCAGAAAA GTTGTGGAGC ATGGCCTGTT TGTCAAGCAC TGCAAAGTCG AGGTGTATTT GCTGGAACTG AAGCTCTGTG AGAACAGTGA CCCCACCAAT GTGCTGAGTT GCCATTTCAG CAAGGCAGAC ACCATTGCAA CCATCGAGAA AGAGATGCGG AAGCTATTCA ACATCCCTGC GGAGCGTGAA ACACGGCTCT GGAACAAATA CATGAGCAAC ACCTACGAGC AGTTGAGCAA GCTAGACAAC ACTGTCCAGG ATGCTGGGCT ATACCAGGGT CAGGTGCTAG TAATTGAGCC TCAAAATGAA GATGGCACAT GGCCCAGGCA GACCTTGCAG TCAAAATCAA GCACTGCGCC TAGCAGAAAT TTTACTACCT CTCCAAAATC ATCAGCAAGT CCCTATTCCT CAGTGTCTGC CTCTCTCATT GCAAATGGTG ATAGCACTAG CACCTGTGGG ATGCACAGTT CCGGTGTCAG CAGGGGTGGA TCTGGCTTTT CTGCTTCGTA TAATTGTCAG GAGCCACCAT CCTCTCATAT ACAACCTGGG CTCTGTGGAC TTGGAAACCT GGGAAACACC TGCTTCATGA ACTCCGCTTT GCAGTGTTTG AGCAACACTG CACCACTGAC TGACTACTTT CTCAAAGATG AGTATGAAGC CGAAATCAAC AGAGACAACC CTCTGGGGAT GAAAGGGGAA ATTGCAGAAG CCTATGCTGA ACTCATTAAG CAGATGTGGT CTGGAAGGGA CGCCCATGTG GCACCTCGCA TGTTCAAAAC TCAAGTAGGA CGTTTTGCTC CTCAATTTTC TGGCTACCAG CAACAAGATT CTCAGGAGCT GCTGGCCTTT CTTCTAGATG GATTGCATGA AGATCTGAAC CGGGTAAAGA AAAAGCCCTA CTTGGAGCTG AAGGATGCCA ATGGGCGGCC AGATGCGGTG GTGGCAAAGG AAGCCTGGGA GAATCACAGG TTGAGGAATG ATTCTGTGAT TGTGGATACT TTCCATGGCC TCTTCAAATC TACTTTGGGT TGCCCAGAAT GTGCTAAGGT TTCTGTGACC TTTGACCCAT TTTGCTATCT AACGCTGCCA CTGCCCTTGA AGAAAGATCG AGTTATGGAG GTTTTCCTGG TTCCTGCTGA CCCTCACTGC AGACCTACTC AGTACCGTGT GACTGTGCCG CTGATGGGGG CTGTGTCCGA CCTGTGCGAG GCTCTCTCCA GGCTGTCTGG CATTGCTGCA GAAAATATGG TGGTCGCAGA TGTGTATAAT CACCGATTCC ACAAAATTTT CCAAATGGAT GAAGGTTTAA ACCACATCAT GCCTCGGGAT GACATTTTCG TGTACGAGGT CTGCAGCACT TCCGTGGATG GCTCGGAATG TGTCACGCTT CCAGTCTACT TCAGGGAGAG GAAGTCCAGG CCATCAAGCA CTTCCTCCGC ATCAGCGCTA TATGGGCAGC CACTATTGCT TTCTGTCCCC AAGCACAAGT TAACCCTTGA GTCTTTGTAC CAGGCTGTTT GTGATCGTAT CAGCCGCTAT GTGAAACAGC CTTTACCTGA TGAGTTTGGC AGCTCACCCT TGGAGCCAGG GGCCTGCAAT GGCTCCAGGA ACAGCTGTGA AGGAGAAGAT GAGGAAGAAA TGGAGCATCA GGAAGAAGGC AAAGAGCAGC TTTCAGAAAC AGAAGGCAGT GGGGAAGATG AGCCAGGAAA TGACCCCAGT GAGACCACCC AAAAGAAGAT CAAAGGCCAG CCCTGCCCAA AAAGGCTTTT TACCTTCAGT CTTGTGAACT CCTATGGAAC AGCTGACATA AATTCACTTG CAGCTGATGG AAAACTACTT AAACTCAACT CTCGATCTAC ACTGGCCATG GATTGGGACA GTGAAACTCG GAGACTTTAC TATGATGAGC AAGAATCTGA GGCCTACGAG AAGCATGTGA GCATGTTGCA GCCTCAGAAG AAGAAGAAGA CCACAGTGGC CCTGAGAGAC TGCATCGAGC TCTTCACCAC CATGGAGACC CTTGGGGAGC ATGACCCCTG GTACTGTCCC AACTGTAAGA AGCATCAACA GGCCACAAAA AAGTTTGACC TATGGTCCTT GCCCAAGATC CTGGTGGTCC ACCTCAAACG TTTCTCCTAC AACAGATACT GGAGGGATAA GCTCGACACA GTCGTAGAAT TCCCAATCAG AGGGCTGAAC ATGTCCGAGT TTGTCTGTAA CCTGTCAGCA AGGCCTTATG TGTACGACCT CATTGCCGTG TCCAATCATT ATGGAGCCAT GGGGGTTGGC CACTACACTG CATATGCGAA GAACAAACTG AATGGTAAAT GGTATTACTT TGATGATAGC AACGTGTCCC TGGCCTCTGA GGATCAGATA GTGACTAAAG CAGCTTATGT GCTATTTTAC CAACGTCGAG ATGATGAATT TTATAAGACA CCTTCACTTA GCAGTTCTGG TTCCTCTGAT GGAGGGACAC GACCAAGCAG CTCTCAGCAG GGCTTTGGGG ATGATGAGGC TTGCAGCATG GACACCAACT AA. It is sometimes possible for the material contained within the vial of "USP4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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