USP15 cdna clone
USP15 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Uniprot Description
USP15: Protease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 12q14
Cellular Component: cytoplasm; nucleus
Molecular Function: cysteine-type endopeptidase activity; identical protein binding; protein binding; SMAD binding; transforming growth factor beta receptor binding; ubiquitin-specific protease activity
Biological Process: BMP signaling pathway; protein deubiquitination; transforming growth factor beta receptor signaling pathway
Research Articles on USP15
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Product Notes
The USP15 usp15 (Catalog #AAA1277252) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggaag gcggagcggc ggatctggac acccagcggt ctgacatcgc gacgctgctc aaaacctcgc tccggaaagg ggacacctgg tacctagtcg atagtcgctg gttcaaacag tggaaaaaat atgttggctt tgacagttgg gacaaatacc agatgggaga tcaaaatgtg tatcctggac ccattgataa ctctggactt ctcaaagatg gtgatgccca gtcacttaag gaacacctta ttgatgaatt ggattacata ctgttgccaa ctgaaggttg gaataaactt gtcagctggt acacattgat ggaaggtcaa gagccaatag cacgaaaggt ggttgaacag ggtatgtttg taaagcactg caaagtagaa gtatatctca cagaattgaa gctatgtgaa aatggaaaca tgaataatgt tgtaactcga agatttagca aagctgacac aatagataca attgaaaagg aaataagaaa aatcttcagt attccagatg aaaaggagac cagattgtgg aacaaataca tgagtaacac atttgaacca ctgaataaac cagacagcac cattcaggat gctggtttat accaaggaca ggtattagtg atagaacaga aaaatgaaga tggaacatgg ccaaggggtc cttctactcc taaaaagcca ctagagcaga gttgctag. It is sometimes possible for the material contained within the vial of "USP15, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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