UGT1A4 cdna clone
UGT1A4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]
Uniprot Description
UGT1A4: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Defects in UGT1A4 are the cause of Gilbert syndrome (GILBS). Gilbert syndrome occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague nonspecific complaints. Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 1 (CN1). CN1 patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive. Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 2 (CN2). CN2 patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Endoplasmic reticulum; Carbohydrate Metabolism - pentose and glucuronate interconversions; Cofactor and Vitamin Metabolism - retinol; Membrane protein, integral; EC 2.4.1.17; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Transferase; Carbohydrate Metabolism - ascorbate and aldarate; Lipid Metabolism - androgen and estrogen
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding
Biological Process: bilirubin conjugation; flavonoid biosynthetic process; heme catabolic process
Disease: Crigler-najjar Syndrome, Type I; Gilbert Syndrome
Research Articles on UGT1A4
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Product Notes
The UGT1A4 ugt1a4 (Catalog #AAA1265949) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCAGAG GACTCCAGGT TCCCCTGCCG CGGCTGGCCA CAGGACTGCT GCTCCTCCTC AGTGTCCAGC CCTGGGCTGA GAGTGGAAAG GTGTTGGTGG TGCCCACTGA TGGCAGCCCC TGGCTCAGCA TGCGGGAGGC CTTGCGGGAG CTCCATGCCA GAGGCCACCA GGCGGTGGTC CTCACCCCAG AGGTGAATAT GCACATCAAA GAAGAGAAAT TTTTCACCCT GACAGCCTAT GCTGTTCCAT GGACCCAGAA GGAATTTGAT CGCGTTACGC TGGGCTACAC TCAAGGGTTC TTTGAAACAG AACATCTTCT GAAGAGATAT TCTAGAAGTA TGGCAATTAT GAACAATGTA TCTTTGGCCC TTCATAGGTG TTGTGTGGAG CTACTGCATA ATGAGGCCCT GATCAGGCAC CTGAATGCTA CTTCCTTTGA TGTGGTTTTA ACAGACCCCG TTAACCTCTG CGGGGCGGTG CTGGCTAAGT ACCTGTCGAT TCCTGCTGTG TTTTTTTGGA GGTACATTCC ATGTGACTTA GACTTTAAGG GCACACAGTG TCCAAATCCT TCCTCCTATA TTCCTAAGTT ACTAACGACC AATTCAGACC ACATGACATT CCTGCAAAGG GTCAAGAACA TGCTCTACCC TCTGGCCCTG TCCTACATTT GCCATACTTT TTCTGCCCCT TATGCAAGTC TTGCCTCTGA GCTTTTTCAG AGAGAGGTGT CAGTGGTGGA TCTTGTCAGC TATGCATCCG TGTGGCTGTT CCGAGGGGAC TTTGTGATGG ACTACCCCAG GCCGATCATG CCCAACATGG TCTTCATTGG GGGCATCAAC TGTGCCAACG GGAAGCCACT ATCTCAGGAA TTTGAAGCCT ACATTAATGC TTCTGGAGAA CATGGAATTG TGGTTTTCTC TTTGGGATCA ATGGTCTCAG AAATTCCAGA GAAGAAAGCT ATGGCAATTG CTGATGCTTT GGGCAAAATC CCTCAGACAG TCCTGTGGCG GTACACTGGA ACCCGACCAT CGAATCTTGC GAACAACACG ATACTTGTTA AGTGGCTACC CCAAAACGAT CTGCTTGGTC ACCCGATGAC CCGTGCCTTT ATCACCCATG CTGGTTCCCA TGGTGTTTAT GAAAGCATAT GCAATGGCGT TCCCATGGTG ATGATGCCCT TGTTTGGTGA TCAGATGGAC AATGCAAAGC GCATGGAGAC TAAGGGAGCT GGAGTGACCC TGAATGTTCT GGAAATGACT TCTGAAGATT TAGAAAATGC TCTAAAAGCA GTCATCAATG ACAAAAGTTA CAAGGAGAAC ATCATGCGCC TCTCCAGCCT TCACAAGGAC CGCCCGGTGG AGCCGCTGGA CCTGGCCGTG TTCTGGGTGG AGTTTGTGAT GAGGCACAAG GGCGCGCCAC ACCTGCGCCC CGCAGCCCAC GACCTCACCT GGTACCAGTA CCATTCCTTG GACGTGATTG GTTTCCTCTT GGCCGTCGTG CTGACAGTGG CCTTCATCAC CTTTAAATGT TGTGCTTATG GCTACCGGAA ATGCTTGGGG AAAAAAGGGC GAGTTAAGAA AGCCCACAAA TCCAAGACCC ATTGA. It is sometimes possible for the material contained within the vial of "UGT1A4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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