UBE2L6 cdna clone
UBE2L6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
Uniprot Description
UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: cytosol; nucleoplasm
Molecular Function: protein binding; ubiquitin binding; ubiquitin-protein ligase activity
Biological Process: bypass DNA synthesis; cellular protein metabolic process; negative regulation of interferon type I production; protein modification process
Research Articles on UBE2L6
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Product Notes
The UBE2L6 ube2l6 (Catalog #AAA1276216) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgatggcga gcatgcgagt ggtgaaggag ctggaggatc ttcagaagaa gcctccccca tacctgcgga acctgtccag cgatgatgcc aatgtcctgg tgtggcacgc tctcctccta cccgaccaac ctccctacca cctgaaagcc ttcaacctgc gcatcagctt cccgccggag tatccgttca agcctcccat gatcaaattc acaaccaaga tctaccaccc caacgtggac gagaacggac agatttgcct gcccatcatc agcagtgaga actggaagcc ttgcaccaag acttgccaag tcctggaggc cctcaatgtg ctggtgaata gaccgaatat cagggagccc ctgcggatgg acctcgctga cctgctgaca cagaatccgg agctgttcag aaagaatgcc gaagagttca ccctccgatt cggagtggac cggccctcct aa. It is sometimes possible for the material contained within the vial of "UBE2L6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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