TP53BP1 cdna clone
TP53BP1 cDNA Clone
Gene Names
TP53BP1; TP53; p202; 53BP1; TDRD30; p53BP1
Synonyms
TP53BP1; TP53BP1 cDNA Clone; TP53BP1 cdna clone
Sequence
atggaccctactggaagtcagttggattcagatttctctcagcaagatactccttgcctgataattgaagattctcagcctgaaagccaggttctagaggatgattctggttctcacttcagtatgctatctcgacaccttcctaatctccagacgcacaaagaaaatcctgtgttggatgttgtgtccaatcctgaacaaacagctggagaagaacgaggagacggtaatagtgggttcaatgaacatttgaaagaaaacaaggttgcagaccctgtggattcttctaacttggacacatgtggttccatcagtcaggtcattgagcagttacctcagccaaacaggacaagcagtgttctgggaatgtcagtggaatctgctcctgctgtggaggaagagaagggagaagagttggaacagaaggagaaagagaaggaagaagatacttcaggcaatactacacattcccttggtgctgaagatactgcctcatcacagttgggttttggggttctggaactctcccagagccaggatgttgaggaaaatactgtgccatatgaagtggacaaagagcagctacaatcagtaaccaccaactctggttataccaggctgtctgatgtggatgctaatactgcaattaagcatgaagaacagtccaacgaagatatccccatagcagaacagtccagcaaggacatccctgtgacagcacagcccagtaaggatgtacatgttgtaaaagagcaaaatccaccacctgcaaggtcagaggacatgccttttagccccaaagcatctgttgctgctatggaagcaaaagaacagttgtctgcacaagaacttatggaaagtggactgcagattcagaagtcaccagagcctgaggttttgtcaactcaggaagacttgtttgaccagagcaataaaacagtatcttctgatggttgctctactccttcaagggaggaaggtgggtgttctttggcttccactcctgccaccactctgcatctcctgcagctctctggtcagaggtcccttgttcaggacagtctttccacgaattcttcagatcttgttgctccttctcctgatgctttccgatctactccttttatcgttcctagcagtcccacagagcaagaagggagacaagataagccaatggacacgtcagtgttatctgaagaaggaggagagccttttcagaagaaacttcaaagtggtgaaccagtggagttagaaaacccccctctcctgcctgagtccactgtatcaccacaagcctcaacaccaatatctcagagcacaccagtcttccctcctgggtcacttcctatcccatcccagcctcagttttctcatgacatttttattccttccccaagtctggaagaacaatcaaatgatgggaagaaagatggagatatgcatagttcatctttgacagttgagtgttctaaaacttcagagattgaaccaaagaattcccctgaggatcttgggctatctttgacaggggattcttgcaagttgatgctttctacaagtgaatatagtcagtccccaaagatggagagcttgagttctcacagaattgatgaagatggagaaaacacacagattgaggatacggaacccatgtctccagttctcaattctaaatttgttcctgctgaaaatgatagtatcctgatgaatccagcacaggatggtgaagtacaactgagtcagaatgatgacaaaacaaagggagatgatacagacaccagggatgacattagtattttagccactggttgcaagggcagagaagaaacggtagcagaagatgtttgtattgatctcacttgtgattcggggagtcaggcagttccgtcaccagctactcgatctgaggcactttctagtgtgttagatcaggaggaagctatggaaattaaagaacaccatccagaggaggggtcttcagggtctgaggtggaagaaatccctgagacaccttgtgaaagtcaaggagaggaactcaaagaagaaaatatggagagtgttccgttgcacctttctctgactgaaactcagtcccaagggttgtgtcttcaaaaggaaatgccaaaaaaagaatgctcagaagctatggaagttgaaaccagtgtgattagtattgattcccctcaaaagttggcaatacttgaccaagaattggaacataaggaacaggaagcttgggaagaagctacttcagaggactccagtgttgtcattgtagatgtgaaagagccatctcccagagttgatgtttcttgtgaacctttggagggagtggagaagtgctcagattcccagtcatgggaggatattgctccagaaatagaaccatgtgctgagaatagattagacaccaaggaagaaaagagtgtagaatatgaaggagatctgaaatcagggactgcagaaacagaacctgtagagcaagattcttcacagccttccttacctttagtgagagcagatgatcctttaagacttgaccaggagttgcagcagccccaaactcaggagaaaacaagtaattcattaacagaagactcaaaaatggctaatgcaaagcagctaagctcagatgcagaggcccagaagctggggaagccctctgcccatgcctcacaaagcttctgtgaaagttctagtgaaaccccatttcatttcactttgcctaaagaaggtgatatcatcccaccattgactggtgcaaccccacctcttattgggcacctaaaattggagcccaagagacacagtactcctattggtattagcaactatccagaaagcaccatagcaaccagtgatgtcatgtctgaaagcatggtggagacccatgatcccatacttgggagtggaaaaggggattctggggctgccccagacgtggatgataaattatgtctaagaatgaaactggttagtcctgagactgaggcgagtgaagagtctttgcagttcaacctggaaaagcctgcaactggtgaaagaaaaaatggatctactgctgttgctgagtctgttgccagtccccagaagaccatgtctgtgttgagctgtatctgtgaagccaggcaagagaatgaggctcgaagtgaggatccccccaccacacccatcagggggaacttgctccactttccaagttctcaaggagaagaggagaaagaaaaattggagggtgaccatacaatcaggcagagtcaacagcctatgaagcccattagtcctgtcaaggaccctgtttctcctgcttcccagaagatggtcatacaagggccatccagtcctcaaggagaggcaatggtgacagatgtgctagaagaccagaaagaaggacggagtactaataaggaaaatcctagtaaggccttgattgaaaggcccagccaaaataacataggaatccaaaccatggagtgttccttgagggtcccagaaactgtttcagcagcaacccagactataaagaatgtgtgtgagcaggggaccagtacagtggaccagaactttggaaagcaagatgccacagttcagactgagagggggagtggtgagaaaccagtcagtgctcctggggatgatacagagtcgctccatagccagggagaagaagagtttgatatgcctcagcctccacatggccatgtcttacatcgtcacatgagaacaatccgggaagtacgcacacttgtcactcgtgtcattacagatgtgtattatgtggatggaacagaagtagaaagaaaagtaactgaggagactgaagagccaattgtagagtgtcaggagtgtgaaactgaagtttccccttcacagactgggggctcctcaggtgacctgggggatatcagctccttctcctccaaggcatccagcttacaccgcacatcaagtgggacaagtctctcagctatgcacagcagtggaagctcagggaaaggagccggaccactcagagggaaaaccagcgggacagaacccgcagattttgccttacccagctcccgaggaggcccaggaaaactgagtcctagaaaaggggtcagtcagacagggacgccagtgtgtgaggaggatggtgatgcaggccttggcatcagacagggagggaaggctccagtcacgcctcgtgggcgtgggcgaaggggccgcccaccttctcggaccactggaaccagagaaacagctgtgcctggccccttgggcatagaggacatttcacctaacttgtcaccagatgataaatccttcagccgtgtcgtgccccgagtgccagactccaccagacgaacagatgtgggtgctggtgctttgcgtcgtagtgactctccagaaattcctttccaggctgctgctggcccttctgatggcttagatgcctcctctccaggaaatagctttgtagggctccgtgttgtagccaagtggtcatccaatggctacttttactctgggaaaatcacacgagatgtcggagctgggaagtataaattgctctttgatgatgggtacgaatgtgatgtgttgggcaaagacattctgttatgtgaccccatcccgctggacactgaagtgacggccctctcggaggatgagtatttcagtgcaggagtggtgaaaggacataggaaggagtctggggaactgtactacagcattgaaaaagaaggccaaagaaagtggtataagcgaatggctgtcatcctgtccttggagcaaggaaacagactgagagagcagtatgggcttggcccctatgaagcagtaacacctcttacaaaggcagcagatatcagcttagacaatttggtggaagggaagcggaaacggcgcagtaacgtcagctccccagccacccctactgcctccagtagcagcagcacaacccctacccgaaagatcacagaaagtcctcgtgcctccatgggagttctctcaggcaaaagaaaacttatcacttctgaagaggaacggtcccctgccaagcgaggtcgcaagtctgccacagtaaaacctggtgcagtaggggcaggagagtttgtgagcccctgtgagagtggagacaacaccggtgaaccctctgccctggaagagcagagagggcctttgcctctcaacaagaccttgtttctgggctacgcatttctccttaccatggccacaaccagtgacaagttggccagccgctccaaactgccagatggtcctacaggaagcagtgaagaagaggaggaatttttggaaattcctcctttcaacaagcagtatacagaatcccagcttcgagcaggagctggctatatccttgaagatttcaatgaagcccagtgtaacacagcttaccagtgtcttctaattgcggatcagcattgtcgaacccggaagtacttcctgtgccttgccagtgggattccttgtgtgtctcatgtctgggtccatgatagttgccatgccaaccagctccagaactaccgtaattatctgttgccagctgggtacagccttgaggagcaaagaattctggactggcaaccccgtgaaaatcctttccagaatctgaaggtactcttggtatcagaccaacagcagaacttcctggagctctggtctgagatcctcatgactggtggtgcagcctctgtgaagcagcaccattcaagtgcccataacaaagatattgctttaggggtatttgatgtggtggtgacggacccctcatgcccagcctcggtgctgaagtgtgctgaagcattgcagctgcctgtggtgtcacaagagtgggtgatccagtgcctcattgttggggagagaattggattcaagcagcatccaaaatataaacacgattatgtttctcactaa
Sequence Length
5919
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
213,989 Da
NCBI Official Full Name
Homo sapiens tumor protein p53 binding protein 1, mRNA
NCBI Official Synonym Full Names
tumor protein p53 binding protein 1
NCBI Official Symbol
TP53BP1
NCBI Official Synonym Symbols
TP53; p202; 53BP1; TDRD30; p53BP1
NCBI Protein Information
tumor suppressor p53-binding protein 1
UniProt Protein Name
Tumor suppressor p53-binding protein 1
Protein Family
UniProt Gene Name
TP53BP1
UniProt Synonym Gene Names
53BP1; p53-binding protein 1; p53BP1
UniProt Entry Name
TP53B_HUMAN
Uniprot Description
53BP1: a DNA damage checkpoint protein that interacts with HDAC4 protein to mediate the DNA damage response. Inhibits E2F1-mediated apoptosis in prostate cancer cells. Recruited to double strand breaks via the binding of its Tudor domain to dimethylated H3 K20. Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Binds to the central domain of p53. Interacts with Artemis. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on S139. Interacts with histone H4 that has been dimethylated at K20. Has low affinity for histone H4 containing monomethylated K20. Does not bind histone H4 containing unmethylated or trimethylated K20. Has low affinity for histone H3 that has been dimethylated on K79. Does not bind unmethylated histone H3. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Two alternatively spliced human isoforms have been observed.
Protein type: Transcription, coactivator/corepressor; DNA repair, damage
Chromosomal Location of Human Ortholog: 15q15-q21
Cellular Component: chromosome, telomeric region; cytoplasm; nucleoplasm; nucleus
Molecular Function: methylated histone residue binding; p53 binding; protein binding
Biological Process: DNA damage checkpoint; double-strand break repair via nonhomologous end joining; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; response to DNA damage stimulus
Research Articles on TP53BP1
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Product Notes
The TP53BP1 tp53bp1 (Catalog #AAA1270015) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggacccta ctggaagtca gttggattca gatttctctc agcaagatac tccttgcctg ataattgaag attctcagcc tgaaagccag gttctagagg atgattctgg ttctcacttc agtatgctat ctcgacacct tcctaatctc cagacgcaca aagaaaatcc tgtgttggat gttgtgtcca atcctgaaca aacagctgga gaagaacgag gagacggtaa tagtgggttc aatgaacatt tgaaagaaaa caaggttgca gaccctgtgg attcttctaa cttggacaca tgtggttcca tcagtcaggt cattgagcag ttacctcagc caaacaggac aagcagtgtt ctgggaatgt cagtggaatc tgctcctgct gtggaggaag agaagggaga agagttggaa cagaaggaga aagagaagga agaagatact tcaggcaata ctacacattc ccttggtgct gaagatactg cctcatcaca gttgggtttt ggggttctgg aactctccca gagccaggat gttgaggaaa atactgtgcc atatgaagtg gacaaagagc agctacaatc agtaaccacc aactctggtt ataccaggct gtctgatgtg gatgctaata ctgcaattaa gcatgaagaa cagtccaacg aagatatccc catagcagaa cagtccagca aggacatccc tgtgacagca cagcccagta aggatgtaca tgttgtaaaa gagcaaaatc caccacctgc aaggtcagag gacatgcctt ttagccccaa agcatctgtt gctgctatgg aagcaaaaga acagttgtct gcacaagaac ttatggaaag tggactgcag attcagaagt caccagagcc tgaggttttg tcaactcagg aagacttgtt tgaccagagc aataaaacag tatcttctga tggttgctct actccttcaa gggaggaagg tgggtgttct ttggcttcca ctcctgccac cactctgcat ctcctgcagc tctctggtca gaggtccctt gttcaggaca gtctttccac gaattcttca gatcttgttg ctccttctcc tgatgctttc cgatctactc cttttatcgt tcctagcagt cccacagagc aagaagggag acaagataag ccaatggaca cgtcagtgtt atctgaagaa ggaggagagc cttttcagaa gaaacttcaa agtggtgaac cagtggagtt agaaaacccc cctctcctgc ctgagtccac tgtatcacca caagcctcaa caccaatatc tcagagcaca ccagtcttcc ctcctgggtc acttcctatc ccatcccagc ctcagttttc tcatgacatt tttattcctt ccccaagtct ggaagaacaa tcaaatgatg ggaagaaaga tggagatatg catagttcat ctttgacagt tgagtgttct aaaacttcag agattgaacc aaagaattcc cctgaggatc ttgggctatc tttgacaggg gattcttgca agttgatgct ttctacaagt gaatatagtc agtccccaaa gatggagagc ttgagttctc acagaattga tgaagatgga gaaaacacac agattgagga tacggaaccc atgtctccag ttctcaattc taaatttgtt cctgctgaaa atgatagtat cctgatgaat ccagcacagg atggtgaagt acaactgagt cagaatgatg acaaaacaaa gggagatgat acagacacca gggatgacat tagtatttta gccactggtt gcaagggcag agaagaaacg gtagcagaag atgtttgtat tgatctcact tgtgattcgg ggagtcaggc agttccgtca ccagctactc gatctgaggc actttctagt gtgttagatc aggaggaagc tatggaaatt aaagaacacc atccagagga ggggtcttca gggtctgagg tggaagaaat ccctgagaca ccttgtgaaa gtcaaggaga ggaactcaaa gaagaaaata tggagagtgt tccgttgcac ctttctctga ctgaaactca gtcccaaggg ttgtgtcttc aaaaggaaat gccaaaaaaa gaatgctcag aagctatgga agttgaaacc agtgtgatta gtattgattc ccctcaaaag ttggcaatac ttgaccaaga attggaacat aaggaacagg aagcttggga agaagctact tcagaggact ccagtgttgt cattgtagat gtgaaagagc catctcccag agttgatgtt tcttgtgaac ctttggaggg agtggagaag tgctcagatt cccagtcatg ggaggatatt gctccagaaa tagaaccatg tgctgagaat agattagaca ccaaggaaga aaagagtgta gaatatgaag gagatctgaa atcagggact gcagaaacag aacctgtaga gcaagattct tcacagcctt ccttaccttt agtgagagca gatgatcctt taagacttga ccaggagttg cagcagcccc aaactcagga gaaaacaagt aattcattaa cagaagactc aaaaatggct aatgcaaagc agctaagctc agatgcagag gcccagaagc tggggaagcc ctctgcccat gcctcacaaa gcttctgtga aagttctagt gaaaccccat ttcatttcac tttgcctaaa gaaggtgata tcatcccacc attgactggt gcaaccccac ctcttattgg gcacctaaaa ttggagccca agagacacag tactcctatt ggtattagca actatccaga aagcaccata gcaaccagtg atgtcatgtc tgaaagcatg gtggagaccc atgatcccat acttgggagt ggaaaagggg attctggggc tgccccagac gtggatgata aattatgtct aagaatgaaa ctggttagtc ctgagactga ggcgagtgaa gagtctttgc agttcaacct ggaaaagcct gcaactggtg aaagaaaaaa tggatctact gctgttgctg agtctgttgc cagtccccag aagaccatgt ctgtgttgag ctgtatctgt gaagccaggc aagagaatga ggctcgaagt gaggatcccc ccaccacacc catcaggggg aacttgctcc actttccaag ttctcaagga gaagaggaga aagaaaaatt ggagggtgac catacaatca ggcagagtca acagcctatg aagcccatta gtcctgtcaa ggaccctgtt tctcctgctt cccagaagat ggtcatacaa gggccatcca gtcctcaagg agaggcaatg gtgacagatg tgctagaaga ccagaaagaa ggacggagta ctaataagga aaatcctagt aaggccttga ttgaaaggcc cagccaaaat aacataggaa tccaaaccat ggagtgttcc ttgagggtcc cagaaactgt ttcagcagca acccagacta taaagaatgt gtgtgagcag gggaccagta cagtggacca gaactttgga aagcaagatg ccacagttca gactgagagg gggagtggtg agaaaccagt cagtgctcct ggggatgata cagagtcgct ccatagccag ggagaagaag agtttgatat gcctcagcct ccacatggcc atgtcttaca tcgtcacatg agaacaatcc gggaagtacg cacacttgtc actcgtgtca ttacagatgt gtattatgtg gatggaacag aagtagaaag aaaagtaact gaggagactg aagagccaat tgtagagtgt caggagtgtg aaactgaagt ttccccttca cagactgggg gctcctcagg tgacctgggg gatatcagct ccttctcctc caaggcatcc agcttacacc gcacatcaag tgggacaagt ctctcagcta tgcacagcag tggaagctca gggaaaggag ccggaccact cagagggaaa accagcggga cagaacccgc agattttgcc ttacccagct cccgaggagg cccaggaaaa ctgagtccta gaaaaggggt cagtcagaca gggacgccag tgtgtgagga ggatggtgat gcaggccttg gcatcagaca gggagggaag gctccagtca cgcctcgtgg gcgtgggcga aggggccgcc caccttctcg gaccactgga accagagaaa cagctgtgcc tggccccttg ggcatagagg acatttcacc taacttgtca ccagatgata aatccttcag ccgtgtcgtg ccccgagtgc cagactccac cagacgaaca gatgtgggtg ctggtgcttt gcgtcgtagt gactctccag aaattccttt ccaggctgct gctggccctt ctgatggctt agatgcctcc tctccaggaa atagctttgt agggctccgt gttgtagcca agtggtcatc caatggctac ttttactctg ggaaaatcac acgagatgtc ggagctggga agtataaatt gctctttgat gatgggtacg aatgtgatgt gttgggcaaa gacattctgt tatgtgaccc catcccgctg gacactgaag tgacggccct ctcggaggat gagtatttca gtgcaggagt ggtgaaagga cataggaagg agtctgggga actgtactac agcattgaaa aagaaggcca aagaaagtgg tataagcgaa tggctgtcat cctgtccttg gagcaaggaa acagactgag agagcagtat gggcttggcc cctatgaagc agtaacacct cttacaaagg cagcagatat cagcttagac aatttggtgg aagggaagcg gaaacggcgc agtaacgtca gctccccagc cacccctact gcctccagta gcagcagcac aacccctacc cgaaagatca cagaaagtcc tcgtgcctcc atgggagttc tctcaggcaa aagaaaactt atcacttctg aagaggaacg gtcccctgcc aagcgaggtc gcaagtctgc cacagtaaaa cctggtgcag taggggcagg agagtttgtg agcccctgtg agagtggaga caacaccggt gaaccctctg ccctggaaga gcagagaggg cctttgcctc tcaacaagac cttgtttctg ggctacgcat ttctccttac catggccaca accagtgaca agttggccag ccgctccaaa ctgccagatg gtcctacagg aagcagtgaa gaagaggagg aatttttgga aattcctcct ttcaacaagc agtatacaga atcccagctt cgagcaggag ctggctatat ccttgaagat ttcaatgaag cccagtgtaa cacagcttac cagtgtcttc taattgcgga tcagcattgt cgaacccgga agtacttcct gtgccttgcc agtgggattc cttgtgtgtc tcatgtctgg gtccatgata gttgccatgc caaccagctc cagaactacc gtaattatct gttgccagct gggtacagcc ttgaggagca aagaattctg gactggcaac cccgtgaaaa tcctttccag aatctgaagg tactcttggt atcagaccaa cagcagaact tcctggagct ctggtctgag atcctcatga ctggtggtgc agcctctgtg aagcagcacc attcaagtgc ccataacaaa gatattgctt taggggtatt tgatgtggtg gtgacggacc cctcatgccc agcctcggtg ctgaagtgtg ctgaagcatt gcagctgcct gtggtgtcac aagagtgggt gatccagtgc ctcattgttg gggagagaat tggattcaag cagcatccaa aatataaaca cgattatgtt tctcactaa. It is sometimes possible for the material contained within the vial of "TP53BP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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