TNRC6A cdna clone
TNRC6A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Uniprot Description
TNRC6A: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Belongs to the GW182 family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Translation; RNA-binding
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm
Molecular Function: protein binding
Biological Process: miRNA-mediated gene silencing; miRNA-mediated gene silencing, negative regulation of translation; phosphoinositide-mediated signaling; RNA-mediated gene silencing; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway
Research Articles on TNRC6A
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Product Notes
The TNRC6A tnrc6a (Catalog #AAA1266689) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagcacg gcccgctgat cacattccac ctgaacctcc ctcacggaaa tgctctggtc cgctacagtt caaaagaaga ggtagtgaag gcacaaaagt ctctgcacat gtgtgtactg gggaacacta ctattcttgc tgagtttgcc agtgaagagg agatcagtcg tttctttgca caaagccagt ctctgacccc ttctcccggc tggcagtctc tcgggtccag ccagagccgg ctgggctccc tcgactgttc ccactcattc tccagccgga ccgatctcaa tcactggaat ggtgctgggc tgtcgggaac taactgtgga gaccttcacg gcacttcact ctgggggacc ccgcattatt ccacaagcct gtggggtccc ccaagcagca gcgacccccg aggaattagc agcccatctc ccattaacgc ttttctttct gttgaccacc tgggtggggg tggagagtcc atgtaa. It is sometimes possible for the material contained within the vial of "TNRC6A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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