TNIP1 cdna clone
TNIP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
TNIP1: Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3 seems not to be required for this function. Inhibits NF-kappa-B activation by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcricption. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflamation; this function is mediated by association with SELPLG and dependent on phosohorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Interacts with TNFAIP3 and IKBKG; facilitates TNFAIP3- mediated de-ubiquitination of NEMO/IKBKG. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IKBKG (polyubiquitinated). Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 5q32-q33.1
Cellular Component: cytoplasm; intracellular; nucleoplasm
Molecular Function: mitogen-activated protein kinase binding; protein binding; ubiquitin-specific protease activity
Biological Process: defense response; glycoprotein biosynthetic process; leukocyte adhesion; MyD88-dependent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral genome replication; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; translation
Research Articles on TNIP1
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Product Notes
The TNIP1 tnip1 (Catalog #AAA1267787) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaaggga gaggaccgta ccggatctac gaccctgggg gcagcgtgcc ctcaggagag gcatccgcag cttttgagcg cctagtgaag gagaattccc ggctgaagga aaaaatgcaa gggataaaga tgttagggga gcttttggaa gagtcccaga tggaagcgac caggctccgg cagaaggcag aggagctagt gaaggacaac gagctgctcc caccaccttc tccctccttg ggctccttcg accccctggc tgagctcaca ggaaaggact caaatgtcac agcatctccc acagcccctg catgccccag tgacaagcca gcaccagtcc agaagcctcc atccagtggc acctcctctg aatttgaagt ggtcactcct gaggagcaga attcaccaga gagcagcagc catgccaatg cgatggcgct gggccccctg ccccgtgagg acggcaacct gatgctgcac ctgcagcgcc tggagaccac gctgagtgtg tgtgccgagg agccggacca cggccagctc ttcacccacc tgggccgcat ggccctggag ttcaaccgac tggcatccaa ggtgcacaag aatgagcagc gcacctccat tctgcagacc ctgtgtgagc agcttcggaa ggagaacgag gctctgaagg ccaagttgga taagggcctg gaacagcggg atcaggctgc cgagaggctg cgggaggaaa atttggagct caagaagttg ttgatgagca atggcaacaa agagggtgcg tctgggcggc caggctcacc gaagatggaa gggacaggca agaaggcagt ggctggacag cagcaggcta gtgtgacggc aggtaaggtc ccagaggtgg tggccttggg cgcagccgag aagaaggtga agatgctgga gcagcagcgc agtgagctgc tggaagtgaa caagcagtgg gaccagcatt tccggtccat gaagcagcag tatgagcaga agatcactga gctgcgtcag aagctggctg atttgcagaa gcaggtgact gacctggagg ccgagcggga gcagaagcag cgtgactttg accgcaagct cctcctggcc aagtccaaga ttgaaatgga ggagaccgac aaggagcagc tgacagcaga ggccaaggag ctgcgccaaa aggtcaagta cctgcaggat cagctgagcc cactcacccg acagcgtgag taccaggaaa aggagatcca gcggctcaac aaggccctgg aggaagcact gagcatccaa accccgccat catctccacc aacagcattt gggagcccag aaggagcagg ggccctccta aggaaacagg agctggtcac gcagaatgag ttgctgaaac agcaggtgaa gatcttcgag gaggacttcc agagggagcg cagtgatcgt gagcgcatga atgaggagaa ggaagagctg aagaagcaag tggagaagct gcaggcccag gtcaccctgt caaatgccca gctaaaagca ttcaaagatg aggagaaggc aagagaagcc ctcagacagc agaagaggaa agcaaaggcc tcaggagagc gttaccatgt ggagccccac ccagaacatc tctgcggggc ctacccctac gcctacccgc ccatgccagc catggtgcca caccatggct tcgaggactg gtcccagatc cgctaccccc ctccccccat ggccatggag cacccgcccc cactccccaa ctcgcgcctc ttccatctgc cggaatacac ctggcgtcta ccctgtggag gggttcgaaa tccaaatcag agctcccaag tgatggaccc tcccacagcc aggcctacag aaccagagtc tccaaaaaaa tga. It is sometimes possible for the material contained within the vial of "TNIP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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