TMC8 cdna clone
TMC8 cDNA Clone
Gene Names
TMC8; EV2; EVER2; EVIN2
Synonyms
TMC8; TMC8 cDNA Clone; TMC8 cdna clone
Sequence
ATGCTGCTGCCGCGGTCGGTGTCATCGGAGCGGGCCCCTGGGGTGCCGGAGCCGGAGGAGCTGTGGGAGGCAGAGATGGAGCGGCTGCGCGGCTCTGGGACGCCCGTGCGCGGGCTGCCCTATGCCATGATGGACAAGCGCCTCATCTGGCAGCTGCGGGAGCCCGTGGGGGTGCAGACCTTGCGCTGGCAGCGGTGGCAGCGCCGGCGGCAGACGGTGGAAAGGCGCCTGCGGGAGGCAGCGCAGCGGCTGGCCCGGGGCCTTGGGCTCTGGGAGGGGGCGCTCTACGAGATCGGGGGCCTCTTCGGCACAGGAATTCGGTCCTACTTCACCTTCCTCCGCTTCCTGCTGCTACTCAACCTGCTGAGCCTGCTGCTCACCGCAAGCTTCGTGCTGCTGCCCCTGGTCTGGCTCCGCCCCCCTGACCCAGGCCCCACCCTGAACTTGACCCTCCAGTGCCCTGGTAGCCGCCAGTCCCCGCCTGGCGTTTTGAGGTTCCACAATCAACTTTGGCATGTTTTGACTGGCAGGGCCTTCACCAACACCTATCTCTTCTACGGTGCGTACCGAGTGGGGCCGGAGAGCAGCTCCGTGTACAGCATCCGCCTGGCCTACCTCCTCAGCCCGCTGGCCTGCCTGCTCCTCTGCTTCTGTGGGACTCTGCGGCGGATGGTGAAGGGGCTGCCGCAGAAGACTCTGCTGGGTCAGGGCTATCAGGCGCCTCTCAGCGCCAAGGTCTTCTCCTCATGGGACTTCTGCATCCGGGTGCAGGAAGCAGCCACCATCAAGAAGCATGAGATCAGCAACGAGTTCAAGGTGGAGCTGGAGGAGGGCCGTCGCTTCCAGCTGATGCAGCAGCAGACCCGGGCCCAGACGGCCTGCCGCCTGCTCTCCTACCTGCGGGTCAACGTACTCAACGGGCTCCTGGTGGTTGGGGCCATCAGCGCCATCTTCTGGGCTACCAAGTACTCACAGGACAACAAGGAGGAGTCCCTGTTTCTGCTGCTCCAGTACCTGCCCCCTGGGGTCATCGCCCTGGTCAACTTCCTGGGTCCCCTGCTGTTCACATTTCTGGTCCAGCTGGAGAACTACCCTCCCAACACGGAGGTCAACCTCACTCTGATCTGGTGCGTGGTGCTGAAGCTGGCCAGCTTGGGGATGTTCTCCGTCTCCCTGGGTCAGACCATACTGTGCATTGGCAGAGACAAGAGCAGCTGTGAGTCCTACGGCTACAACGTTTGTGACTATCAGTGCTGGGAGAACTCCGTGGGGGAGGAGCTGTACAAGCTGAGTATCTTCAACTTCCTCCTCACCGTGGCCTTCGCCTTCCTGGTCACCCTGCCTCGGAGGCTGCTGGTGGACCGGTTCTCAGGCCGGTTCTGGGCCTGGCTGGAACGGGAGGAGTTCCTGGTCCCCAAGAATGTGCTGGACATCGTGGCGGGGCAGACGGTCACCTGGATGGGCCTCTTCTACTGCCCCCTGCTGCCCCTGCTGAATAGCGTCTTCCTCTTCCTCACCTTCTACATCAAGAAGTACACCCTCCTGAAGAACTCCAGGGCATCTTCGCGGCCCTTCCGTGCCTCCAGCTCCACCTTCTTCTTCCAGCTAGTGCTCCTCCTGGGCCTGCTTCTGGCTGCAGTGCCCCTGGGCTATGTGGTCAGCAGCATCCACTCCTCCTGGGACTGCGGCCTCTTCACCAACTACTCAGCACCCTGGCAAGTGGTCCCGGAGCTGGTGGCCCTTGGGCTCCCGCCCATTGGCCAGCGTGCCCTCCACTACCTGGGCTCCCACGCCTTCAGCTTCCCCCTCCTCATCATGCTCAGCCTTGTCCTGACGGTGTGCGTCTCCCAGACCCAGGCCAATGCCAGGGCCATCCACAGGCTCCGGAAGCAGCTGGTGTGGCAGGTTCAGGAGAAGTGGCACCTGGTGGAGGACCTGTCGCGACTGCTGCCGGAGCCAGGCCCGAGCGACTCTCCGGGCCCCAAGTACCCTGCCTCCCAAGCTTCGCGCCCGCAGTCCTTCTGCCCCGGATGCCCATGCCCTGGCTCCCCGGGCCACCAGGCCCCGCGGCCGGGCCCCTCCGTCGTGGATGCCGCGGGACTGCGTTCCCCTTGCCCTGGACAGCACGGTGCCCCGGCCTCCGCCCGCAGATTCCGCTTCCCCAGCGGCGCGGAGCTGTAA
Sequence Length
2181
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
56,132 Da
NCBI Official Full Name
Homo sapiens transmembrane channel-like 8, mRNA
NCBI Official Synonym Full Names
transmembrane channel like 8
NCBI Official Symbol
TMC8
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
NCBI Protein Information
transmembrane channel-like protein 8
UniProt Protein Name
Transmembrane channel-like protein 8
Protein Family
UniProt Gene Name
TMC8
UniProt Synonym Gene Names
EVER2; EVIN2
UniProt Entry Name
TMC8_HUMAN
NCBI Description
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Uniprot Description
TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytoplasm; endoplasmic reticulum; extracellular space; Golgi apparatus; nuclear membrane
Molecular Function: protein binding; receptor binding
Biological Process: negative regulation of protein binding; negative regulation of protein oligomerization; regulation of cell growth; zinc ion homeostasis
Disease: Epidermodysplasia Verruciformis
Research Articles on TMC8
Similar Products
Product Notes
The TMC8 tmc8 (Catalog #AAA1275728) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCTGCTGC CGCGGTCGGT GTCATCGGAG CGGGCCCCTG GGGTGCCGGA GCCGGAGGAG CTGTGGGAGG CAGAGATGGA GCGGCTGCGC GGCTCTGGGA CGCCCGTGCG CGGGCTGCCC TATGCCATGA TGGACAAGCG CCTCATCTGG CAGCTGCGGG AGCCCGTGGG GGTGCAGACC TTGCGCTGGC AGCGGTGGCA GCGCCGGCGG CAGACGGTGG AAAGGCGCCT GCGGGAGGCA GCGCAGCGGC TGGCCCGGGG CCTTGGGCTC TGGGAGGGGG CGCTCTACGA GATCGGGGGC CTCTTCGGCA CAGGAATTCG GTCCTACTTC ACCTTCCTCC GCTTCCTGCT GCTACTCAAC CTGCTGAGCC TGCTGCTCAC CGCAAGCTTC GTGCTGCTGC CCCTGGTCTG GCTCCGCCCC CCTGACCCAG GCCCCACCCT GAACTTGACC CTCCAGTGCC CTGGTAGCCG CCAGTCCCCG CCTGGCGTTT TGAGGTTCCA CAATCAACTT TGGCATGTTT TGACTGGCAG GGCCTTCACC AACACCTATC TCTTCTACGG TGCGTACCGA GTGGGGCCGG AGAGCAGCTC CGTGTACAGC ATCCGCCTGG CCTACCTCCT CAGCCCGCTG GCCTGCCTGC TCCTCTGCTT CTGTGGGACT CTGCGGCGGA TGGTGAAGGG GCTGCCGCAG AAGACTCTGC TGGGTCAGGG CTATCAGGCG CCTCTCAGCG CCAAGGTCTT CTCCTCATGG GACTTCTGCA TCCGGGTGCA GGAAGCAGCC ACCATCAAGA AGCATGAGAT CAGCAACGAG TTCAAGGTGG AGCTGGAGGA GGGCCGTCGC TTCCAGCTGA TGCAGCAGCA GACCCGGGCC CAGACGGCCT GCCGCCTGCT CTCCTACCTG CGGGTCAACG TACTCAACGG GCTCCTGGTG GTTGGGGCCA TCAGCGCCAT CTTCTGGGCT ACCAAGTACT CACAGGACAA CAAGGAGGAG TCCCTGTTTC TGCTGCTCCA GTACCTGCCC CCTGGGGTCA TCGCCCTGGT CAACTTCCTG GGTCCCCTGC TGTTCACATT TCTGGTCCAG CTGGAGAACT ACCCTCCCAA CACGGAGGTC AACCTCACTC TGATCTGGTG CGTGGTGCTG AAGCTGGCCA GCTTGGGGAT GTTCTCCGTC TCCCTGGGTC AGACCATACT GTGCATTGGC AGAGACAAGA GCAGCTGTGA GTCCTACGGC TACAACGTTT GTGACTATCA GTGCTGGGAG AACTCCGTGG GGGAGGAGCT GTACAAGCTG AGTATCTTCA ACTTCCTCCT CACCGTGGCC TTCGCCTTCC TGGTCACCCT GCCTCGGAGG CTGCTGGTGG ACCGGTTCTC AGGCCGGTTC TGGGCCTGGC TGGAACGGGA GGAGTTCCTG GTCCCCAAGA ATGTGCTGGA CATCGTGGCG GGGCAGACGG TCACCTGGAT GGGCCTCTTC TACTGCCCCC TGCTGCCCCT GCTGAATAGC GTCTTCCTCT TCCTCACCTT CTACATCAAG AAGTACACCC TCCTGAAGAA CTCCAGGGCA TCTTCGCGGC CCTTCCGTGC CTCCAGCTCC ACCTTCTTCT TCCAGCTAGT GCTCCTCCTG GGCCTGCTTC TGGCTGCAGT GCCCCTGGGC TATGTGGTCA GCAGCATCCA CTCCTCCTGG GACTGCGGCC TCTTCACCAA CTACTCAGCA CCCTGGCAAG TGGTCCCGGA GCTGGTGGCC CTTGGGCTCC CGCCCATTGG CCAGCGTGCC CTCCACTACC TGGGCTCCCA CGCCTTCAGC TTCCCCCTCC TCATCATGCT CAGCCTTGTC CTGACGGTGT GCGTCTCCCA GACCCAGGCC AATGCCAGGG CCATCCACAG GCTCCGGAAG CAGCTGGTGT GGCAGGTTCA GGAGAAGTGG CACCTGGTGG AGGACCTGTC GCGACTGCTG CCGGAGCCAG GCCCGAGCGA CTCTCCGGGC CCCAAGTACC CTGCCTCCCA AGCTTCGCGC CCGCAGTCCT TCTGCCCCGG ATGCCCATGC CCTGGCTCCC CGGGCCACCA GGCCCCGCGG CCGGGCCCCT CCGTCGTGGA TGCCGCGGGA CTGCGTTCCC CTTGCCCTGG ACAGCACGGT GCCCCGGCCT CCGCCCGCAG ATTCCGCTTC CCCAGCGGCG CGGAGCTGTA A. It is sometimes possible for the material contained within the vial of "TMC8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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