TLR8 cdna clone
TLR8 cDNA Clone
Gene Names
TLR8; CD288
Synonyms
TLR8; TLR8 cDNA Clone; TLR8 cdna clone
Sequence
ATGGAAAACATGTTCCTTCAGTCGTCAATGCTGACCTGCATTTTCCTGCTAATATCTGGTTCCTGTGAGTTATGCGCCGAAGAAAATTTTTCTAGAAGCTATCCTTGTGATGAGAAAAAGCAAAATGACTCAGTTATTGCAGAGTGCAGCAATCGTCGACTACAGGAAGTTCCCCAAACGGTGGGCAAATATGTGACAGAACTAGACCTGTCTGATAATTTCATCACACACATAACGAATGAATCATTTCAAGGGCTGCAAAATCTCACTAAAATAAATCTAAACCACAACCCCAATGTACAGCACCAGAACGGAAATCCCGGTATACAATCAAATGGCTTGAATATCACAGACGGGGCATTCCTCAACCTAAAAAACCTAAGGGAGTTACTGCTTGAAGACAACCAGTTACCCCAAATACCCTCTGGTTTGCCAGAGTCTTTGACAGAACTTAGTCTAATTCAAAACAATATATACAACATAACTAAAGAGGGCATTTCAAGACTTATAAACTTGAAAAATCTCTATTTGGCCTGGAACTGCTATTTTAACAAAGTTTGCGAGAAAACTAACATAGAAGATGGAGTATTTGAAACGCTGACAAATTTGGAGTTGCTATCACTATCTTTCAATTCTCTTTCACACGTGCCACCCAAACTGCCAAGCTCCCTACGCAAACTTTTTCTGAGCAACACCCAGATCAAATACATTAGTGAAGAAGATTTCAAGGGATTGATAAATTTAACATTACTAGATTTAAGCGGGAACTGTCCGAGGTGCTTCAATGCCCCATTTCCATGCGTGCCTTGTGATGGTGGTGCTTCAATTAATATAGATCGTTTTGCTTTTCAAAACTTGACCCAACTTCGATACCTAAACCTCTCTAGCACTTCCCTCAGGAAGATTAATGCTGCCTGGTTTAAAAATATGCCTCATCTGAAGGTGCTGGATCTTGAATTCAACTATTTAGTGGGAGAAATAGCCTCTGGGGCATTTTTAACGATGCTGCCCCGCTTAGAAATACTTGACTTGTCTTTTAACTATATAAAGGGGAGTTATCCACAGCATATTAATATTTCCAGAAACTTCTCTAAACTTTTGTCTCTACGGGCATTGCATTTAAGAGGTTATGTGTTCCAGGAACTCAGAGAAGATGATTTCCAGCCCCTGATGCAGCTTCCAAACTTATCGACTATCAACTTGGGTATTAATTTTATTAAGCAAATCGATTTCAAACTTTTCCAAAATTTCTCCAATCTGGAAATTATTTACTTGTCAGAAAACAGAATATCACCGTTGGTAAAAGATACCCGGCAGAGTTATGCAAATAGTTCCTCTTTTCAACGTCATATCCGGAAACGACGCTCAACAGATTTTGAGTTTGACCCACATTCGAACTTTTATCATTTCACCCGTCCTTTAATAAAGCCACAATGTGCTGCTTATGGAAAAGCCTTAGATTTAAGCCTCAACAGTATTTTCTTCATTGGGCCAAACCAATTTGAAAATCTTCCTGACATTGCCTGTTTAAATCTGTCTGCAAATAGCAATGCTCAAGTGTTAAGTGGAACTGAATTTTCAGCCATTCCTCATGTCAAATATTTGGATTTGACAAACAATAGACTAGACTTTGATAATGCTAGTGCTCTTACTGAATTGTCCGACTTGGAAGTTCTAGATCTCAGCTATAATTCACACTATTTCAGAATAGCAGGCGTAACACATCATCTAGAATTTATTCAAAATTTCACAAATCTAAAAGTTTTAAACTTGAGCCACAACAACATTTATACTTTAACAGATAAGTATAACCTGGAAAGCAAGTCCCTGGTAGAATTAGTTTTCAGTGGCAATCGCCTTGACATTTTGTGGAATGATGATGACAACAGGTATATCTCCATTTTCAAAGGTCTCAAGAATCTGACACGTCTGGATTTATCCCTTAATAGGCTGAAGCACATCCCAAATGAAGCATTCCTTAATTTGCCAGCGAGTCTCACTGAACTACATATAAATGATAATATGTTAAAGTTTTTTAACTGGACATTACTCCAGCAGTTTCCTCGTCTCGAGTTGCTTGACTTACGTGGAAACAAACTACTCTTTTTAACTGATAGCCTATCTGACTTTACATCTTCCCTTCGGACACTGCTGCTGAGTCATAACAGGATTTCCCACCTACCCTCTGGCTTTCTTTCTGAAGTCAGTAGTCTGAAGCACCTCGATTTAAGTTCCAATCTGCTAAAAACAATCAACAAATCCGCACTTGAAACTAAGACCACCACCAAATTATCTATGTTGGAACTACACGGAAACCCCTTTGAATGCACCTGTGACATTGGAGATTTCCGAAGATGGATGGATGAACATCTGAATGTCAAAATTCCCAGACTGGTAGATGTCATTTGTGCCAGTCCTGGGGATCAAAGAGGGAAGAGTATTGTGAGTCTGGAGCTAACAACTTGTGTTTCAGATGTCACTGCAGTGATATTATTTTTCTTCACGTTCTTTATCACCACCATGGTTATGTTGGCTGCCCTGGCTCACCATTTGTTTTACTGGGATGTTTGGTTTATATATAATGTGTGTTTAGCTAAGGTAAAAGGCTACAGGTCTCTTTCCACATCCCAAACTTTCTATGATGCTTACGTTTCTTATGACACCAAAGATGCCTCTGTTACTGACTGGGTGATAAATGAGCTGCGCTACCACCTTGAAGAGAGCCGAGACAAAAACGTTCTCCTTTGTCTAGAGGAGAGGGATTGGGACCCGGGATTGGCCATCATCGACAACCTCATGCAGAGCATCAACCAAAGCAAGAAAACAGTATTTGTTTTAACCAAAAAATATGCAAAAAGCTGGAACTTTAAAACAGCTTTTTACTTGGCTTTGCAGAGGCTAATGGATGAGAACATGGATGTGATTATATTTATCCTGCTGGAGCCAGTGTTACAGCATTCTCAGTATTTGAGGCTACGGCAGCGGATCTGTAAGAGCTCCATCCTCCAGTGGCCTGACAACCCGAAGGCAGAAGGCTTGTTTTGGCAAACTCTGAGAAATGTGGTCTTGACTGAAAATGATTCACGGTATAACAATATGTATGTCGATTCCATTAAGCAATACTAA
Sequence Length
3126
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
121,764 Da
NCBI Official Full Name
Homo sapiens toll-like receptor 8, mRNA
NCBI Official Synonym Full Names
toll like receptor 8
NCBI Official Symbol
TLR8
NCBI Official Synonym Symbols
CD288
NCBI Protein Information
toll-like receptor 8
UniProt Protein Name
Toll-like receptor 8
Protein Family
UniProt Gene Name
TLR8
UniProt Entry Name
TLR8_HUMAN
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
Uniprot Description
TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to membrane
Molecular Function: DNA binding; double-stranded RNA binding; RNA binding; single-stranded RNA binding
Biological Process: defense response to virus; I-kappaB kinase/NF-kappaB cascade; immunoglobulin mediated immune response; positive regulation of innate immune response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-8 biosynthetic process; response to virus; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Research Articles on TLR8
Similar Products
Product Notes
The TLR8 tlr8 (Catalog #AAA1269744) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAAAACA TGTTCCTTCA GTCGTCAATG CTGACCTGCA TTTTCCTGCT AATATCTGGT TCCTGTGAGT TATGCGCCGA AGAAAATTTT TCTAGAAGCT ATCCTTGTGA TGAGAAAAAG CAAAATGACT CAGTTATTGC AGAGTGCAGC AATCGTCGAC TACAGGAAGT TCCCCAAACG GTGGGCAAAT ATGTGACAGA ACTAGACCTG TCTGATAATT TCATCACACA CATAACGAAT GAATCATTTC AAGGGCTGCA AAATCTCACT AAAATAAATC TAAACCACAA CCCCAATGTA CAGCACCAGA ACGGAAATCC CGGTATACAA TCAAATGGCT TGAATATCAC AGACGGGGCA TTCCTCAACC TAAAAAACCT AAGGGAGTTA CTGCTTGAAG ACAACCAGTT ACCCCAAATA CCCTCTGGTT TGCCAGAGTC TTTGACAGAA CTTAGTCTAA TTCAAAACAA TATATACAAC ATAACTAAAG AGGGCATTTC AAGACTTATA AACTTGAAAA ATCTCTATTT GGCCTGGAAC TGCTATTTTA ACAAAGTTTG CGAGAAAACT AACATAGAAG ATGGAGTATT TGAAACGCTG ACAAATTTGG AGTTGCTATC ACTATCTTTC AATTCTCTTT CACACGTGCC ACCCAAACTG CCAAGCTCCC TACGCAAACT TTTTCTGAGC AACACCCAGA TCAAATACAT TAGTGAAGAA GATTTCAAGG GATTGATAAA TTTAACATTA CTAGATTTAA GCGGGAACTG TCCGAGGTGC TTCAATGCCC CATTTCCATG CGTGCCTTGT GATGGTGGTG CTTCAATTAA TATAGATCGT TTTGCTTTTC AAAACTTGAC CCAACTTCGA TACCTAAACC TCTCTAGCAC TTCCCTCAGG AAGATTAATG CTGCCTGGTT TAAAAATATG CCTCATCTGA AGGTGCTGGA TCTTGAATTC AACTATTTAG TGGGAGAAAT AGCCTCTGGG GCATTTTTAA CGATGCTGCC CCGCTTAGAA ATACTTGACT TGTCTTTTAA CTATATAAAG GGGAGTTATC CACAGCATAT TAATATTTCC AGAAACTTCT CTAAACTTTT GTCTCTACGG GCATTGCATT TAAGAGGTTA TGTGTTCCAG GAACTCAGAG AAGATGATTT CCAGCCCCTG ATGCAGCTTC CAAACTTATC GACTATCAAC TTGGGTATTA ATTTTATTAA GCAAATCGAT TTCAAACTTT TCCAAAATTT CTCCAATCTG GAAATTATTT ACTTGTCAGA AAACAGAATA TCACCGTTGG TAAAAGATAC CCGGCAGAGT TATGCAAATA GTTCCTCTTT TCAACGTCAT ATCCGGAAAC GACGCTCAAC AGATTTTGAG TTTGACCCAC ATTCGAACTT TTATCATTTC ACCCGTCCTT TAATAAAGCC ACAATGTGCT GCTTATGGAA AAGCCTTAGA TTTAAGCCTC AACAGTATTT TCTTCATTGG GCCAAACCAA TTTGAAAATC TTCCTGACAT TGCCTGTTTA AATCTGTCTG CAAATAGCAA TGCTCAAGTG TTAAGTGGAA CTGAATTTTC AGCCATTCCT CATGTCAAAT ATTTGGATTT GACAAACAAT AGACTAGACT TTGATAATGC TAGTGCTCTT ACTGAATTGT CCGACTTGGA AGTTCTAGAT CTCAGCTATA ATTCACACTA TTTCAGAATA GCAGGCGTAA CACATCATCT AGAATTTATT CAAAATTTCA CAAATCTAAA AGTTTTAAAC TTGAGCCACA ACAACATTTA TACTTTAACA GATAAGTATA ACCTGGAAAG CAAGTCCCTG GTAGAATTAG TTTTCAGTGG CAATCGCCTT GACATTTTGT GGAATGATGA TGACAACAGG TATATCTCCA TTTTCAAAGG TCTCAAGAAT CTGACACGTC TGGATTTATC CCTTAATAGG CTGAAGCACA TCCCAAATGA AGCATTCCTT AATTTGCCAG CGAGTCTCAC TGAACTACAT ATAAATGATA ATATGTTAAA GTTTTTTAAC TGGACATTAC TCCAGCAGTT TCCTCGTCTC GAGTTGCTTG ACTTACGTGG AAACAAACTA CTCTTTTTAA CTGATAGCCT ATCTGACTTT ACATCTTCCC TTCGGACACT GCTGCTGAGT CATAACAGGA TTTCCCACCT ACCCTCTGGC TTTCTTTCTG AAGTCAGTAG TCTGAAGCAC CTCGATTTAA GTTCCAATCT GCTAAAAACA ATCAACAAAT CCGCACTTGA AACTAAGACC ACCACCAAAT TATCTATGTT GGAACTACAC GGAAACCCCT TTGAATGCAC CTGTGACATT GGAGATTTCC GAAGATGGAT GGATGAACAT CTGAATGTCA AAATTCCCAG ACTGGTAGAT GTCATTTGTG CCAGTCCTGG GGATCAAAGA GGGAAGAGTA TTGTGAGTCT GGAGCTAACA ACTTGTGTTT CAGATGTCAC TGCAGTGATA TTATTTTTCT TCACGTTCTT TATCACCACC ATGGTTATGT TGGCTGCCCT GGCTCACCAT TTGTTTTACT GGGATGTTTG GTTTATATAT AATGTGTGTT TAGCTAAGGT AAAAGGCTAC AGGTCTCTTT CCACATCCCA AACTTTCTAT GATGCTTACG TTTCTTATGA CACCAAAGAT GCCTCTGTTA CTGACTGGGT GATAAATGAG CTGCGCTACC ACCTTGAAGA GAGCCGAGAC AAAAACGTTC TCCTTTGTCT AGAGGAGAGG GATTGGGACC CGGGATTGGC CATCATCGAC AACCTCATGC AGAGCATCAA CCAAAGCAAG AAAACAGTAT TTGTTTTAAC CAAAAAATAT GCAAAAAGCT GGAACTTTAA AACAGCTTTT TACTTGGCTT TGCAGAGGCT AATGGATGAG AACATGGATG TGATTATATT TATCCTGCTG GAGCCAGTGT TACAGCATTC TCAGTATTTG AGGCTACGGC AGCGGATCTG TAAGAGCTCC ATCCTCCAGT GGCCTGACAA CCCGAAGGCA GAAGGCTTGT TTTGGCAAAC TCTGAGAAAT GTGGTCTTGA CTGAAAATGA TTCACGGTAT AACAATATGT ATGTCGATTC CATTAAGCAA TACTAA. It is sometimes possible for the material contained within the vial of "TLR8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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