TLR5 cdna clone
TLR5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Uniprot Description
TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q41-q42
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: interleukin-1 receptor binding; receptor activity
Biological Process: defense response to Gram-negative bacterium; inflammatory response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway
Disease: Legionnaire Disease, Susceptibility To; Melioidosis, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1
Research Articles on TLR5
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Product Notes
The TLR5 tlr5 (Catalog #AAA1267647) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGAGACC ACCTGGACCT TCTCCTAGGA GTGGTGCTCA TGGCCGGTCC TGTGTTTGGA ATTCCTTCCT GCTCCTTTGA TGGCCGAATA GCCTTTTATC GTTTCTGCAA CCTCACCCAG GTCCCCCAGG TCCTCAACAC CACTGAGAGG CTCCTGCTGA GCTTCAACTA TATCAGGACA GTCACTGCTT CATCCTTCCC CTTTCTGGAA CAGCTGCAGC TGCTGGAGCT CGGGAGCCAG TATACCCCCT TGACTATTGA CAAGGAGGCC TTCAGAAACC TGCCCAACCT TAGAATCTTG GACCTGGGAA GTAGTAAGAT ATACTTCTTG CATCCAGATG CTTTTCAGGG ACTGTTCCAT CTGTTTGAAC TTAGACTGTA TTTCTGTGGT CTCTCTGATG CTGTATTGAA AGATGGTTAT TTCAGAAATT TAAAGGCTTT AACTCGCTTG GATCTATCCA AAAATCAGAT TCGTAGCCTT TACCTTCATC CTTCATTTGG GAAGTTGAAT TCCTTAAAGT CCATAGATTT TTCCTCCAAC CAAATATTCC TTGTATGTGA ACATGAGCTC GAGCCCCTAC AAGGGAAAAC GCTCTCCTTT TTTAGCCTCG CAGCTAATAG CTTGTATAGC AGAGTCTCAG TGGACTGGGG AAAATGTATG AACCCATTCA GAAACATGGT GCTGGAGATA CTAGATGTTT CTGGAAATGG CTGGACAGTG GACATCACAG GAAACTTTAG CAATGCCATC AGCAAAAGCC AGGCCTTCTC TTTGATTCTT GCCCACCACA TCATGGGTGC CGGGTTTGGC TTCCATAACA TCAAAGATCC TGACCAGAAC ACATTTGCTG GCCTGGCCAG AAGTTCAGTG AGACACCTGG ATCTTTCACA TGGGTTTGTC TTCTCCCTGA ACTCACGAGT CTTTGAGACA CTCAAGGATT TGAAGGTTCT GAACCTTGCC TACAACAAGA TAAATAAGAT TGCAGATGAA GCATTTTACG GACTTGACAA CCTCCAAGTT CTCAATTTGT CATATAACCT TCTGGGGGAA CTTTACAGTT CGAATTTCTA TGGACTACCT AAGGTAGCCT ACATTGATTT GCAAAAGAAT CACATTGCAA TAATTCAAGA CCAAACATTC AAATTCCTGG AAAAATTACG GACCTTGGAT CTCCGAGACA ATGCTCTTAC AACCATTCAT TTTATTCCAA GCATACCCGA TATCTTCTTG AGTGGCAATA AACTAGTGAC TTTGCCAAAG ATCAACCTTA CAGCGAACCT CATCCACTTA TCAGAAAACA GGCTAGAAAA TCTAGATATT CTCTACTTTC TCCTACGGGT ACCTCATCTC CAGATTCTCA TTTTAAATCA AAATCGCTTC TCCTCCTGTA GTGGAGATCA AACCCCTTCA GAGAATCCCA GCTTAGAACA GCTTTTCCTT GGAGAAAATA TGTTGCAACT TGCCTGGGAA ACTGAGCTCT GTTGGGATGT TTTTGAGGGA CTTTCTCATC TTCAAGTTCT GTATTTGAAT CATAACTATC TTAATTCCCT TCCACCAGGA GTATTTAGCC ATCTGACTGC ATTAAGGGGA CTAAGCCTCA ACTCCAACAG GCTGACAGTT CTTTCTCACA ATGATTTACC TGCTAATTTA GAGATCCTGG ACATATCCAG GAACCAGCTC CTAGCTCCTA ATCCTGATGT ATTTGTATCA CTTAGTGTCT TGGATATAAC TCATAACAAG TTCATTTGTG AATGTGAACT TAGCACTTTT ATCAATTGGC TTAATCACAC CAATGTCACT ATAGCTGGGC CTCCTGCAGA CATATATTGT GTGTACCCTG ACTCGTTCTC TGGGGTTTCC CTCTTCTCTC TTTCCACGGA AGGTTGTGAT GAAGAGGAAG TCTTAAAGTC CCTAAAGTTC TCCCTTTTCA TTGTATGCAC TGTCACTCTG ACTCTGTTCC TCATGACCAT CCTCACAGTC ACAAAGTTCC GGGGCTTCTG TTTTATCTGT TATAAGACAG CCCAGAGACT GGTGTTCAAG GACCATCCCC AGGGCACAGA ACCTGATATG TACAAATATG ATGCCTATTT GTGCTTCAGC AGCAAAGACT TCACATGGGT GCAGAATGCT TTGCTCAAAC ACCTGGACAC TCAATACAGT GACCAAAACA GATTCAACCT GTGCTTTGAA GAAAGAGACT TTGTCCCAGG AGAAAACCGC ATTGCCAATA TCCAGGATGC CATCTGGAAC AGTAGAAAGA TCGTTTGTCT TGTGAGCAGA CACTTCCTTA GAGATGGCTG GTGCCTTGAA GCCTTCAGTT ATGCCCAGGG CAGGTGCTTA TCTGACCTTA ACAGTGCTCT CATCATGGTG GTGGTTGGGT CCTTGTCCCA GTACCAGTTG ATGAAACATC AATCCATCAG AGGCTTTGTA CAGAAACAGC AGTATTTGAG GTGGCCTGAG GATCTCCAGG ATGTTGGCTG GTTTCTTCAT AAACTCTCTC AACAGATACT AAAGAAAGAA AAAGAAAAGA AGAAAGACAA TAACATTCCG TTGCAAACTG TAGCAACCAT CTCCTAA. It is sometimes possible for the material contained within the vial of "TLR5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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