TICAM2 cdna clone
TICAM2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
Uniprot Description
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Research Articles on TICAM2
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Product Notes
The TICAM2 ticam2 (Catalog #AAA1270737) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGTATCG GGAAGTCTAA AATAAATTCC TGCCCTCTTT CTCTCTCTTG GGGTAAAAGG CACAGTGTGG ATACAAGTCC AGGATATCAT GAGTCAGATT CCAAGAAGTC TGAAGATCTA TCCTTGTGTA ATGTTGCTGA GCACAGCAAT ACAACAGAGG GGCCAACAGG AAAGCAGGAG GGAGCTCAGA GCGTGGAAGA GATGTTTGAA GAAGAAGCTG AAGAAGAGGT GTTCCTCAAA TTTGTGATAT TGCATGCAGA AGATGACACA GATGAAGCCC TCAGAGTCCA GAATCTGCTA CAAGATGACT TTGGTATCAA ACCCGGAATA ATCTTTGCTG AGATGCCATG TGGCAGACAG CATTTACAGA ATTTAGATGA TGCTGTAAAT GGGTCTGCAT GGACAATCTT ATTACTGACT GAAAACTTTT TAAGAGATAC TTGGTGTAAT TTCCAGTTCT ATACGTCCCT AATGAACTCC GTTAACAGGC AGCATAAATA CAACTCTGTT ATACCCATGC GGCCCCTGAA CAATCCCCTT CCCCGAGAAA GGACTCCCTT TGCCCTCCAA ACCATCAATG CCTTAGAGGA AGAAAGTCGT GGATTTCCTA CACAAGTAGA AAGAATTTTT CAGGAGTCTG TGTATAAGAC ACAACAAACT ATATGGAAAG AGACAAGAAA TATGGTACAA AGACAATTTA TTGCCTGA. It is sometimes possible for the material contained within the vial of "TICAM2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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