THRSP cdna clone
THRSP
Translation Sequence: MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ AEAPDLYTYFTMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED ESASGELDLE AQFHLHFSSLHHILMHLTEK AQEVTRKYQE MTGQVW
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Uniprot Description
THRSP: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Belongs to the SPOT14 family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein homodimerization activity
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; lipid metabolic process; regulation of lipid biosynthetic process