TBL1XR1 cdna clone
TBL1XR1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Uniprot Description
TBL1XR1: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4. Ubiquitous. Belongs to the WD repeat EBI family.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3q26.32
Cellular Component: histone deacetylase complex; nucleoplasm; nucleus; spindle microtubule; transcriptional repressor complex
Molecular Function: beta-catenin binding; histone binding; protein binding; protein N-terminus binding; transcription corepressor activity
Biological Process: cellular lipid metabolic process; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin
Disease: Mental Retardation, Autosomal Dominant 41; Pierpont Syndrome
Research Articles on TBL1XR1
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Product Notes
The TBL1XR1 tbl1xr1 (Catalog #AAA1273293) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGTATAA GCAGTGATGA GGTCAACTTC TTGGTATATA GATACTTGCA AGAGTCAGGA TTTTCTCATT CAGCATTTAC CTTTGGTATA GAAAGCCATA TCAGTCAGTC CAATATAAAT GGTGCCCTCG TCCCACCCGC TGCATTGATT TCTATCATCC AGAAAGGTCT ACAGTATGTA GAAGCAGAAG TTAGTATTAA TGAGGATGGT ACCTTGTTTG ATGGTCGACC AATAGAGTCT CTGTCCCTGA TAGATGCCGT AATGCCTGAT GTAGTACAAA CAAGACAACA AGCTTATAGA GATAAGCTTG CACAGCAACA GGCAGCAGCT GCTGCAGCTG CCGCAGCTGC AGCCAGCCAA CAAGGATCTG CAAAAAATGG AGAAAACACA GCAAATGGGG AGGAGAATGG AGCACATACT ATAGCAAATA ATCATACTGA TATGATGGAA GTGGATGGGG ATGTTGAAAT CCCTCCTAAT AAAGCTGTTG TGTTGCGGGG CCATGAATCT GAAGTTTTTA TCTGTGCCTG GAACCCTGTT AGTGATCTCC TAGCATCAGG GTCTGGAGAC TCAACAGCAA GAATATGGAA TCTTAGTGAG AACAGCACCA GTGGCTCTAC ACAGTTAGTA CTTAGACATT GTATACGAGA AGGAGGGCAA GATGTTCCAA GCAACAAGGA TGTCACATCT CTAGATTGGA ATAGTGAAGG TACACTTCTA GCAACTGGTT CCTATGATGG GTTTGCCAGA ATATGGACTA AAGATGGTAA CCTTGCTAGC ACCTTAGGGC AGCATAAAGG CCCTATATTT GCATTAAAAT GGAATAAGAA AGGAAATTTC ATCCTAAGTG CTGGAGTAGA CAAGACTACA ATTATTTGGG ACGCACATAC TGGTGAAGCC AAGCAACAGT TTCCTTTTCA TTCAGCACCA GCATTGGATG TTGATTGGCA GAGCAACAAC ACCTTTGCTT CTTGTAGTAC AGATATGTGC ATTCATGTCT GTAAATTAGG ACAAGACAGA CCTATTAAAA CATTCCAAGG ACATACGAAT GAAGTAAATG CTATCAAATG GGACCCAACT GGCAATCTCT TGGCCTCCTG TTCTGACGAC ATGACTTTAA AGATATGGAG TATGAAACAA GACAATTGTG TCCATGATTT GCAAGCACAT AATAAAGAAA TTTATACTAT CAAATGGAGT CCAACAGGAC CAGGGACTAA TAATCCAAAT GCCAACCTTA TGTTAGCAAG TGCATCCTTT GATTCTACTG TTAGGTTATG GGATGTAGAC CGAGGGATAT GCATCCATAC TTTGACAAAA CACCAAGAGC CTGTGTACAG TGTAGCTTTC AGTCCTGATG GCAGGTATCT GGCAAGTGGT TCTTTTGACA AATGTGTACA CATCTGGAAC ACGCAGACAG GTGCTCTAGT TCACAGCTAT AGGGGAACAG GTGGAATATT TGAAGTTTGC TGGAATGCAG CAGGAGACAA AGTTGGAGCC AGTGCATCAG ATGGTTCAGT TTGTGTATTA GACCTTCGGA AATAG. It is sometimes possible for the material contained within the vial of "TBL1XR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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